Evidence map›Paper›PMID 38168185›Full record

ArticlebioRxiv : the preprint server for biology2024

Epigenetic disruption of the RARγ complex impairs its function to bookmark AR enhancer interactions required for enzalutamide sensitivity in prostate cancer.

Sajad A Wani, Shahid Hussain, Jaimie S Gray, Debasis Nayak, Hancong Tang, Lillian M Perez, Mark D Long, Manjunath Siddappa, Christopher J McCabe, Lara E Sucheston-Campbell and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Sajad A WaniDivision of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH 43210.
Shahid HussainDivision of Cancer Biology, Cedars Sinai Cancer, and Los Angeles, CA 90048.
Jaimie S GrayDivision of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH 43210.
Debasis NayakDivision of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH 43210.
Hancong TangDivision of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH 43210.
Lillian M PerezDivision of Cancer Therapeutics, Cedars Sinai Cancer, Departments of Urology and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Mark D LongRoswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263.
Manjunath SiddappaDivision of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH 43210.
Christopher J McCabeInstitute of Metabolism and Systems Research (IMSR), and Centre of Endocrinology, Diabetes and Metabolism (CEDAM), University of Birmingham, Birmingham, UK.
Lara E Sucheston-CampbellDepartment of Cancer Prevention and Control, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Michael R FreemanDivision of Cancer Therapeutics, Cedars Sinai Cancer, Departments of Urology and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Moray J CampbellDivision of Cancer Biology, Cedars Sinai Cancer, and Los Angeles, CA 90048.
Cedars-Sinai Medical Center · USThe Ohio State University · USRoswell Park Comprehensive Cancer Center · USUniversity of Birmingham · GB

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
NCI NIH HHS P30 CA016058
6 · The paper itself

Abstract

The current study in prostate cancer (PCa) focused on the genomic mechanisms at the cross-roads of pro-differentiation signals and the emergence of lineage plasticity. We explored an understudied cistromic mechanism involving RARγ's ability to govern AR cistrome-transcriptome relationships, including those associated with more aggressive PCa features. The RARγ complex in PCa cell models was enriched for canonical cofactors, as well as proteins involved in RNA processing and bookmarking. Identifying the repertoire of miR-96 bound and regulated gene targets, including those recognition elements marked by m6A, revealed their significant enrichment in the RARγ complex. RARγ significantly enhanced the AR cistrome, particularly in active enhancers and super-enhancers, and overlapped with the binding of bookmarking factors. Furthermore, RARγ expression led to nucleosome-free chromatin enriched with H3K27ac, and significantly enhanced the AR cistrome in G

Identifiers

PMID38168185
PMCPMC10760102
OpenAlexW4389849045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.