ArticleNMR in biomedicine2024
The effects of axonal beading and undulation on axonal diameter estimation from diffusion MRI: Insights from simulations in human axons segmented from three-dimensional electron microscopy.
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Article in NMR in biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
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20 citing papers in PubMed, 17 citations in OpenAlex.
- Clinical Soma and Neurite Density Imaging (SANDI): Translational Microstructure Mapping on Clinical 3T MRI Scanners.Magnetic resonance in medicine · 2026Article
- Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter.Magnetic resonance in medicine · 2026Article
- Axon Diameter Mapping in the Living Human Brain with Ultra-High-Gradient Diffusion MRI at 500 mT/m Gradient Strength.Human brain mapping · 2026Article
- Axon Diameter Mapping From Myelin Water Diffusion MRI.IEEE transactions on medical imaging · 2026Article
- White matter microstructure differences in obstructive sleep apnea severity groups assessed by diffusion tensor metrics and biophysical modeling.Scientific reports · 2026Article
- Ultra-high gradient connectomics and microstructure MRI scanner for imaging of human brain circuits across scales.Nature biomedical engineering · 2026Article
- Validating the neurite exchange imaging (NEXI) model of gray matter using Monte Carlo simulations in numerical substrates.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Validating the standard model of diffusion MRI in white matter with numerical substrates.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Histology-informed microstructural diffusion simulations for MRI cancer characterisation-the Histo-μSim framework.Communications biology · 2025Article
- Oscillating gradient spin echo diffusion time effects implicate variations in neurite beading for the heterogeneous reduced diffusion in human acute ischemic stroke lesions.Magnetic resonance in medicine · 2025Article
- Evaluation of diffusion time-dependent changes in radial diffusivity as a surrogate for axon diameter.Magnetic resonance in medicine · 2025Article
- In vivo cortical microstructure mapping using high-gradient diffusion MRI accounting for intercompartmental water exchange effects.NeuroImage · 2025Article
- Quantifying axonal features of human superficial white matter from three-dimensional multibeam serial electron microscopy data assisted by deep learning.NeuroImage · 2025Article
- Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T.Magnetic resonance in medicine · 2025Article
- Intra-voxel angular dispersion of fibers in corpus callosum decreases with healthy aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- MRI-scale histology validates spatial sensitivity of in-vivo MRI-based axon radius estimation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Non-parametric prediction of brain MRI microstructure using transfer learning.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cortical white matter: no longer a silent partner.Frontiers in neuroanatomy · 2025Review
- Revisiting the interpretation of axon diameter mapping using higher-order signal representations.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Hong-Hsi LeeAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0002-3663-6559
Qiyuan TianAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0002-8350-5295
Maxina SheftAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Ricardo Coronado-LeijaCenter for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.
Gabriel Ramos-LlordenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0003-4020-705X
Ali AbdollahzadehCenter for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.ORCID 0000-0001-6234-2012
Els FieremansCenter for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.ORCID 0000-0002-1384-8591
Dmitry S NovikovCenter for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.ORCID 0000-0002-4213-3050
Susie Y HuangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0003-2950-7254
Advanced Imaging Research (United States) · USHarvard University · USMassachusetts General Hospital · US
Funding
TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Riccardo Lattanzi · 2014 to 2026
$19.3MCONNECTOME 2.0: DEVELOPING THE NEXT GENERATION HUMAN MRI SCANNER FOR BRIDGING STUDIES OF THE MICRO-, MESO- AND MACRO-CONNECTOMEU01EB026996 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BASSER, PETER J., HUANG, SUSIE YI · 2018 to 2022
$14.2MTraining and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BRUCE R ROSEN · 2020 to 2026
$10.9MProject 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8MAn Acquisition and Analysis Pipeline for Integrating MRI and Neuropathology in TBI-related Dementia and VCIDU24NS135561 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl, Susie Yi Huang · 2023 to 2026
$6.1MMesoscopic Biomarkers of Neurodegeneration with Diffusion MRIR01NS088040 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FIEREMANS, ELS, NOVIKOV, DMITRY S · 2014 to 2023
$5.2MToward a Validated in Vivo Imaging Marker of Axonal Damage Predictive of Progressive Disability in Multiple SclerosisR01NS118187 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI · 2021 to 2025
$2.8MRevealing tissue microstructure in the brain gray matter in Alzheimer's disease using in vivo high-gradient diffusion MRIDP5OD031854 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HONG HSI · 2021 to 2025
$2.1MNext-generation 3 Tesla Human MRI SystemS10OD032184 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI · 2023 to 2023
$2.0MHybrid TMS/MRI system for regionally tailored causal mapping of human cortical circuits and connectivityUG3EB034875 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BILGIC, BERKIN, HUANG, SUSIE YI · 2023 to 2024
$837kQuantifying Demyelination and Axonal Loss with Diffusion MRIR21NS081230 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FIEREMANS, ELS, KIM, SUNGHEON GENE · 2012 to 2013
$561kExploring the Relationship Between Tau Deposition and Neurovascular Health in Alzheimer's DiseaseR21AG067562 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI, YEN, YI-FEN · 2020 to 2020
$462kNIA NIH HHS K99 AG073506NIA NIH HHS R21 AG067562NIA NIH HHS R21 AG085795NIBIB NIH HHS P41 EB015896NIBIB NIH HHS P41 EB017183NIBIB NIH HHS P41 EB030006NIBIB NIH HHS U01 EB026996NIBIB NIH HHS UG3 EB034875NIDCR NIH HHSNIH HHS DP5 OD031854NIH HHS S10 OD032184NINDS NIH HHS R01 NS088040NINDS NIH HHS R01 NS118187NINDS NIH HHS R21 NS081230NINDS NIH HHS U24 NS135561
Abstract
The increasing availability of high-performance gradient systems in human MRI scanners has generated great interest in diffusion microstructural imaging applications such as axonal diameter mapping. Practically, sensitivity to axon diameter in diffusion MRI is attained at strong diffusion weightings
Indexed as
Diffusion Magnetic Resonance ImagingWhite MatterAxonsHumansMagnetic Resonance ImagingMicroscopy, Electronaxonal diameter mappingaxonal undulationcaliber variationdiffusion MRIMonte Carlo simulationspherical mean signal
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