ArticleCancer imaging : the official publication of the International Cancer Imaging Society2024
The role of dynamic, static, and delayed total-body PET imaging in the detection and differential diagnosis of oncological lesions.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Functional Renal Assessment via Dynamic LAFOVJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Realization of long axial field-of-view PET technology in the clinic and research environment.The British journal of radiology · 2026Review
- Kinetic modeling with total body PET-current status and future applications.The British journal of radiology · 2026Review
- Discriminating inflammation from malignancy with short-dynamic patlak parametric 18 F-FDG PET/CT.European journal of nuclear medicine and molecular imaging · 2026Article
- Next-generation molecular imaging of cardiac fibrosis.The international journal of cardiovascular imaging · 2026Review
- Optimized Detection of Left Ventricular Hyperpolarized [1-Magnetic resonance in medicine · 2026Article
- Whole-Body Dynamic Positron Emission and Computed Tomography (WBD-PET/CT): Latest Developments, Challenges and Opportunities.Diagnostics (Basel, Switzerland) · 2026Review
- The impact of scan time on dynamic [Formula: see text]-FAPI-04 total-body PET parametric imaging generated by deep learning models.EJNMMI physics · 2026Article
- Advancing Positron Imaging with Alginate-Based Tracers: Design, Synthesis, and Radiolabelling Methods.MethodsX · 2026Article
- From imaging heterogeneity to clinical decision: a novel imaging biomarker based on bone marrow kinetics for advanced NSCLC patients in partial response.EJNMMI research · 2026Article
- Clinical added value of LAFOV PET/CT in patients undergoing same-day [18 F]FDG SAFOV PET/CT scans: an initial experience report and explorative study.European journal of nuclear medicine and molecular imaging · 2026Article
- The value of metabolic parameters on dynamicFrontiers in oncology · 2026Article
- Exploring the metabolic landscape of lung adenocarcinoma and squamous cell carcinoma: a total-body [European journal of nuclear medicine and molecular imaging · 2025Article
- Fluorescence lifetime imaging to investigate propofol-induced metabolic alterations in MDA-MB-231 cells.Biomedical optics express · 2025Article
- Utilizing temporal information to assess metabolic heterogeneity: a study ofQuantitative imaging in medicine and surgery · 2025Article
- Dynamic FDG PET/CT imaging: quantitative assessment, advantages and application in the diagnosis of malignant solid tumors.Frontiers in oncology · 2025Review
- Distinct bone metabolic networks identified inFrontiers in medicine · 2025Article
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12 authors.
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Abstract
objectivesCommercialized total-body PET scanners can provide high-quality images due to its ultra-high sensitivity. We compared the dynamic, regular static, and delayed 18F-fluorodeoxyglucose (FDG) scans to detect lesions in oncologic patients on a total-body PET/CT scanner. MATERIALS &
methodsIn all, 45 patients were scanned continuously for the first 60 min, followed by a delayed acquisition. FDG metabolic rate was calculated from dynamic data using full compartmental modeling, whereas regular static and delayed SUV images were obtained approximately 60- and 145-min post-injection, respectively. The retention index was computed from static and delayed measures for all lesions. Pearson's correlation and Kruskal-Wallis tests were used to compare parameters.
resultsThe number of lesions was largely identical between the three protocols, except MRFDG and delayed images on total-body PET only detected 4 and 2 more lesions, respectively (85 total). FDG metabolic rate (MRFDG) image-derived contrast-to-noise ratio and target-to-background ratio were significantly higher than those from static standardized uptake value (SUV) images (P < 0.01), but this is not the case for the delayed images (P > 0.05). Dynamic protocol did not significantly differentiate between benign and malignant lesions just like regular SUV, delayed SUV, and retention index.
conclusionThe potential quantitative advantages of dynamic imaging may not improve lesion detection and differential diagnosis significantly on a total-body PET/CT scanner. The same conclusion applied to delayed imaging. This suggested the added benefits of complex imaging protocols must be weighed against the complex implementation in the future. CLINICAL RELEVANCE: Total-body PET/CT was known to significantly improve the PET image quality due to its ultra-high sensitivity. However, whether the dynamic and delay imaging on total-body scanner could show additional clinical benefits is largely unknown. Head-to-head comparison between two protocols is relevant to oncological management.
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