ArticleArthritis research & therapy2024
Causality between rheumatoid arthritis and the risk of cognitive impairment: a Mendelian randomization study.
Article in Arthritis research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Genetically predicted cognitive performance and risk of meniscal derangement: A 2-sample Mendelian randomization study.Medicine · 2026Article
- Insights Into Late-Onset Rheumatoid Arthritis (LORA): Characteristics (Clinical and Imaging), Comorbidities, and Therapeutic Targets.Geriatrics & gerontology international · 2026Review
- Causal associations between cognitive impairments and retinal diseases: A two-sample Mendelian randomization study.The Journal of international medical research · 2025Article
- Cognitive Impairment in Rheumatoid Arthritis: The Role of Pain, Inflammation, and Multimorbidity in Neuropsychological Outcomes.Biomedicines · 2025Article
- Rheumatoid arthritis and risk of hearing impairment: A genetic correlation and bidirectional Mendelian randomization study.Medicine · 2025Article
- Article
- The association between arthritis and cognitive function impairment in the older adults: Based on the NHANES 2011-2014.PloS one · 2024Article
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Authors and funding
6 authors.
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Abstract
backgroundThere is mounting proof that rheumatoid arthritis (RA) and cognitive decline are related. These studies, however, have not all been uniform, and others have not discovered such a correlation. It is essential to investigate the link between RA and cognitive decline.
methodWe conducted a Mendelian randomization analysis utilizing three different publicly accessible RA GWAS summary datasets and a variety of meticulously verified instrumental variables. We mostly used inverse variance weighting (IVW), as well as MR-Egger, weighted median, MR-PRESSO, and several sensitivity analyses, to figure out the link between RA and cognitive impairment (CI).
resultsOur MR study identified the causality between RA and declining cognitive performance (β = - 0.010, 95% CI of - 0.017 to - 0.003, P = 4.33E-03) and cognitive function (β = - 0.029, 95% CI of - 0.053 to - 0.005, P = 1.93E-02). The consistent direction of the connection is revealed by sensitivity analysis utilizing the weighted median and the MR-Egger method. Furthermore, we reproduced our findings across two additional RA datasets and found identical outcomes, strengthening the validity of our findings.
conclusionThis study offers proof of causality between RA and an increased risk of CI. Our findings highlight the importance of examining RA patients for cognitive ability, which may open up fresh ideas for the prevention of CI.
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