ArticleNature communications2024
Unlocking regioselective meta-alkylation with epoxides and oxetanes via dynamic kinetic catalyst control.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Dual Nickel/Photoredox-Catalyzed Regio- and Enantioselective Alkenylation of Epoxides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dynamic "Deactivation" mechanism enables epoxides ring-opening to prepare α-substituted alcohols.Nature communications · 2026Article
- Alkene Borylation-Hydrogenation Enables Highly Active, Site-Selective Cobalt-Catalyzed Borylation.Journal of the American Chemical Society · 2025Article
- Bis-Cycloruthenated Complexes in Visible Light-Induced C-H Alkylation with Epoxides.Journal of the American Chemical Society · 2025Article
- Precision installation of silyl synthetic handles within arenes by regiocontrolled ruthenium C(Nature catalysis · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Regioselective arene C-H bond alkylation is a powerful tool in synthetic chemistry, yet subject to many challenges. Herein, we report the meta-C-H bond alkylation of aromatics bearing N-directing groups using (hetero)aromatic epoxides as alkylating agents. This method results in complete regioselectivity on both the arene as well as the epoxide coupling partners, cleaving exclusively the benzylic C-O bond. Oxetanes, which are normally unreactive, also participate as alkylating reagents under the reaction conditions. Our mechanistic studies reveal an unexpected reversible epoxide ring opening process undergoing catalyst-controlled regioselection, as key for the observed high regioselectivities.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.