ArticleBMJ open2024
Risk factors for cognitive impairment in middle-aged type 2 diabetic patients: a cross-sectional study.
Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
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14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Prevalence, risk factors, and early prediction of cognitive impairment in patients with diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Association between abdominal obesity and cognitive outcomes in middle-aged adults: a systematic review.Frontiers in nutrition · 2026Pooled it
- Risk factors for mild cognitive impairment in type 2 diabetes: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Effect of non-pharmacological interventions in people with cognitive frailty: a systematic review and network meta-analysis.BMC public health · 2024Pooled it
- Cognitive Impairment in People with Type 2 Diabetes Mellitus: Associations with Inflammatory and Vascular Markers.Annals of neurosciences · 2026Article
- The psychological burden of diabetes: common mental health disorders, their impact on disease outcomes and strategies for intervention.Journal of diabetes and metabolic disorders · 2026Review
- The relationships between diabetic male infertility, diabetic cognitive impairment, and the neuroendocrine-immune network: A review.Medicine · 2026Review
- Association of BMI and Cognitive Performance in the Diabetes Prevention Program Outcomes Study.Obesity (Silver Spring, Md.) · 2025Article
- Prevalence and Predictors of Cognitive Decline Among Diabetes Mellitus Patients Attending Jinja Regional Referral Hospital: A Cross-Sectional Study in Eastern Uganda.Health science reports · 2025Article
- Association Between Anthropometry and Cognitive Impairment in Patients with Type 2 Diabetes: Secondary Analysis from the 'Cognition in Diabetes' Study.TouchREVIEWS in endocrinology · 2025Article
- Article
- Prevalence and pattern of cognitive dysfunction in young adults and middle-aged patients with type-2 diabetes.Journal of family medicine and primary care · 2025Article
- Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats.Immunity & ageing : I & A · 2025Article
- Prevalence of cognitive impairment and its associated factors in type 2 diabetes mellitus patients with hypertension in Hunan, China: a cross-sectional study.Frontiers in psychiatry · 2024Article
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to investigate risk factors for cognitive impairment (CI) and explore the relationship between obesity and cognition in hospitalised middle-aged patients with type 2 diabetes (T2DM).
methodsSubjects were divided into normal cognitive function (NCF) (n=320) and CI (n=204) groups based on the results of the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). The risk factors for CI were determined by logistic regression analysis and generalised linear modelling. The associations between obesity parameters (body mass index (BMI) and waist circumference (WC)) and cognitive ability were studied with the use of linear regression analysis, piecewise regression modelling and interaction analysis. The receiver operating characteristic curve analysis was used to examine the diagnostic value of influencing factors for cc
resultsThe prevalence of CI was 38.9% in hospitalised middle-aged T2DM patients (median age, 58 years). Age, WC, hypoglycaemic episode within past 3 months and cerebrovascular disease (CVD) were identified as independent risk factors for CI, while the independent protective factors were education, diabetic dietary pattern, overweight and obesity. BMI was a protective factor for the MoCA score within a certain range, whereas WC was a risk factor for the MMSE and MoCA scores. The area under the curve for the combination of BMI and WC was 0.754 (p<0.001).
conclusionAge, education, diabetic dietary pattern, WC, overweight, obesity, hypoglycaemic episode in 3 months and CVD may be potential influencing factors for the occurrence of CI in hospitalised middle-aged population with T2DM. The combination of BMI and WC may represent a good predictor for early screening of CI in this population. Nevertheless, more relevant prospective studies are still needed.
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