Evidence map›Paper›PMID 38167099›Full record

ArticleBMC medical genomics2024

Association of MBL2 gene polymorphisms and MBL levels with dilated cardiomyopathy in a Chinese Han population.

Yujie Mao, Hong Wei, Yugang Gong, Lei Peng, Yu Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Impact of Sociodemographic, Clinical, and Genetic Factors andIranian journal of medical sciences · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yujie Mao *Institute of Dermatology and Venereology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Hong Wei *Department of Ophthalmology and Vision Research Laboratory, West China Hospital, Sichuan University, Chengdu, China.
Yugang GongInstitute of Dermatology and Venereology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Lei PengDepartment of Nephrology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. cloudycq@sina.com.
Yu ChenDepartment of Cardiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. polyb@163.com.
University of Electronic Science and Technology of China · CNSichuan University · CN

Funding

the Foundation of Science and Technology Department of Sichuan Province No. 2019YFS0249the Foundation of Science and Technology Department of Sichuan Province No.22NSFSC1165the National Natural Science Foundation of China No. 81600259the National Natural Science Foundation of China No. 82003376the National Natural Science Foundation of China No. 82200767the Natural Science Foundation of Sichuan No. 2023NSFSC0590
6 · The paper itself

Abstract

backgroundIt has been reported that Mannose-binding lectin 2 (MBL2) gene polymorphisms and expression levels are related to dilated cardiomyopathy (DCM). This study aimed to investigate the potential association between MBL2 gene polymorphisms and the pathogenesis of DCM.

methodsFive single nucleotide polymorphisms (SNPs) of the MBL2 gene were genotyped in 440 DCM patients and 532 controls in Southwest China. A luciferase reporter assay was used to detect the transcriptional activity the different genotypes. MBL serum levels, left ventricle ejection fraction (LVEF) and lower left ventricular end-diastolic diameter (LVEDD) were measured.

resultsThe rs11003125 C allele increased the transcriptional activity of the MBL2 promoter compared with the rs11003125 G allele. The rs11003125 CC carriers had higher MBL serum levels, LVEF and LVEDD than the rs11003125 CG and GG carriers.

conclusionsOur study first revealed that MBL2 polymorphisms and serum MBL levels were associated with DCM. Allele C in rs11003125 of MBL2 may upregulate the expression levels of MBL. High serum MBL levels may be a protective factor in DCM pathogenesis.

Indexed as

Cardiomyopathy, DilatedMannose-Binding LectinEast Asian PeopleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideMannose-Binding LectinMBL2 protein, humanDilated cardiomyopathyGeneMannose-binding lectinPolymorphismRisk

Identifiers

PMID38167099
PMCPMC10763076
OpenAlexW4390510876

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.