Evidence map›Paper›PMID 38167066›Full record

ArticleNutrition & metabolism2024

Dysregulation of mitochondrial dynamics mediated aortic perivascular adipose tissue-associated vascular reactivity impairment under excessive fructose intake.

Kay L H Wu, Chih-Wei Wu, Lee-Wei Chen, Hsiao-Huang Chang, Ching-Li Cheng, Cai-Yi Wu, Yu-Chi Lee, I-Chun Chen, Chun-Ying Hung, Wen-Chung Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Kay L H Wu *Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC.
Chih-Wei Wu *Plastic Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC.
Lee-Wei ChenDepartment of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC.
Hsiao-Huang ChangDepartment of Surgery, School of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.
Ching-Li ChengDepartment of Nursing, National Tainan Institute of Nursing, Tainan, Taiwan, ROC.
Cai-Yi WuPlastic Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC.
Yu-Chi LeeInstitute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC.
I-Chun ChenInstitute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC.
Chun-Ying HungInstitute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC.
Wen-Chung LiuPlastic Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC. dliu@vghks.gov.tw.
Kaohsiung Chang Gung Memorial Hospital · TWNational Chiayi University · TWKaohsiung Veterans General Hospital · TWNational Tainan Institute of Nursing · TWNational Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TW

Funding

Kaohsiung Chang Gung Memorial Hospital CMRPG8J0731-33Kaohsiung Veterans General Hospital VGHKS108-121Ministry of Science and Technology, Taiwan MOST 109-2314-B-182A-075B-003-MY3
6 · The paper itself

Abstract

Excessive fructose intake presents the major risk factor for metabolic cardiovascular disease. Perivascular adipose tissue (PVAT) is a metabolic tissue and possesses a paracrine function in regulating aortic reactivity. However, whether and how PVAT alters vascular function under fructose overconsumption remains largely unknown. In this study, male Sprague-Dawley rats (8 weeks old) were fed a 60% high fructose diet (HFD) for 12 weeks. Fasting blood sugar, insulin, and triglycerides were significantly increased by HFD intake. Plasma adiponectin was significantly enhanced in the HFD group. The expression of uncoupling protein 1 (UCP1) and mitochondrial mass were reduced in the aortic PVAT of the HFD group. Concurrently, the expression of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) and mitochondrial transcription factor A (TFAM) were suppressed. Furthermore, decreased fusion proteins (OPA1, MFN1, and MFN2) were accompanied by increased fission proteins (FIS1 and phospho-DRP1). Notably, the upregulated α-smooth muscle actin (α-SMA) and osteocalcin in the PVAT were concurrent with the impaired reactivity of aortic contraction and relaxation. Coenzyme Q

Indexed as

Adipose whiteningHigh fructose dietMitochondrial dynamicsPerivascular adipose tissueVascular reactivity

Identifiers

PMID38167066
PMCPMC10763079
OpenAlexW4390499116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.