ArticleBMC public health2024
Multimorbidity, healthy lifestyle, and the risk of cognitive impairment in Chinese older adults: a longitudinal cohort study.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- A bibliometric analysis on the health behaviors related to mild cognitive impairment.Frontiers in aging neuroscience · 2024Pooled it
- Educational intervention for mental health and health behaviors in elderly Iranian women randomized controlled trial.Scientific reports · 2025Trial
- Association between unhealthy lifestyles and young-onset dementia: a nationwide cohort study.European archives of psychiatry and clinical neuroscience · 2026Article
- Multimorbidity and Cognitive Function in Community-Dwelling Older Adults in Shanghai: The Mediating Role of Sleep Quality.Journal of sleep research · 2026Article
- Establishment of the China Elderly Comorbidity Medical Database (CECMed) and its application in machine learning-based prediction.BMC geriatrics · 2026Article
- Cognitive impairment among widowed older adults in India: a decomposition analysis of gender gap.BMC psychology · 2026Article
- Multidomain Predictors of Four-Year Risk for Dementia and Mild Cognitive Impairment Among Community-Dwelling Korean Older Adults.Healthcare (Basel, Switzerland) · 2026Article
- The latent profile of health literacy among older adults patients with chronic disease comorbidity and its association with self-management behaviors.Frontiers in public health · 2026Article
- Joint associations of lung function of both general and abdominal obesity with cardiometabolic multimorbidity: a cross-sectional study.Frontiers in medicine · 2026Article
- Alexithymia and its subgroup characteristics in Chinese empty-nesters with multiple chronic diseases: an exploration based on latent class analysis.Frontiers in psychiatry · 2026Article
- Association between 24-h activity patterns and inhibitory control in community-dwelling older adults: a cross-sectional study based on chronic disease status.Frontiers in public health · 2026Article
- Sleep quality and life satisfaction in urban-dwelling solitary Chinese older adults: a study of parallel mediation by depression and cognitive function.Frontiers in aging · 2026Article
- The impact of cardiometabolic multimorbidity on cognitive function in older adults: a review.Frontiers in public health · 2026Review
- Grip strength and cognitive function of older adults through the chain mediating effect of life space mobility and depression.Scientific reports · 2025Article
- Association of cardiometabolic multimorbidity and high-risk lifestyle behaviours with subjective cognitive decline: baseline findings from the China ageing and health survey.Journal of global health · 2025Article
- A Network Analysis of Food Intake and Cognitive Function in Older Adults with Multimorbidity: A National Cross-Sectional Study.Nutrients · 2025Article
- Cohort Changes in Cognitive Function Among Mexican Older Adults from 2001 to 2021.The Gerontologist · 2025Article
- Dynamic cross-lagged effects between healthy lifestyles and multimorbidity among middle-aged and older adults in China.BMC public health · 2025Article
- Association of cardiometabolic multimorbidity with postoperative delirium and three-year mortality in patients undergoing knee/hip arthroplasty: a prospective cohort study.International journal of surgery (London, England) · 2025Article
- Cognitive function moderates the mediation of resilience in the relationship between perceived receipt of filial piety and loneliness among community-dwelling older adults with multiple long-term conditions.Scientific reports · 2025Article
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7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEvidence on the association between multimorbidity and cognitive impairment in Chinese older population is limited. In addition, whether a healthy lifestyle can protect cognitive function in multimorbid older population remains unknown.
methodsA total of 6116 participants aged ≥ 65 years from the Chinese Longitudinal Healthy Longevity Survey were followed up repeatedly. The number of coexisting chronic diseases was used for assessing multimorbidity and cardiometabolic multimorbidity. Three lifestyle statuses (unhealthy, intermediate, and healthy) were defined based on a lifestyle score covering smoking, alcohol drinking, body mass index, outdoor activities, and dietary pattern. Cognitive impairment was defined as the Mini-Mental State Examination score < 24. A modified Poisson regression model with robust error variance was used to assess the associations between multimorbidity, healthy lifestyle, and cognitive impairment.
resultsDuring a median follow-up period of 5.8 years, 1621 incident cases of cognitive impairment were identified. The relative risk (RR) of cognitive impairment associated with heavy multimorbidity burden (≥ 3 conditions) was 1.39 (95% confidence interval: 1.22-1.59). This association declined with age, with RRs being 3.08 (1.78-5.31), 1.40 (1.04-1.87), and 1.19 (1.01-1.40) in subjects aged < 70 years, ≥ 70 and < 80 years, and ≥ 80 years, respectively (P for interaction = 0.001). Compared to unhealthy lifestyle, a healthy lifestyle was related to an approximately 40% reduced risk of cognitive impairment regardless of multimorbidity burden. Among the 5 lifestyle factors assessed, daily outdoor activities and a healthy dietary pattern showed convincing protective effects on cognitive function.
conclusionsThe relationship between multimorbidity and cognitive impairment is age-dependent but remains significant in the population aged 80 years or older. A healthy lifestyle may protect cognitive function regardless of the multimorbidity burden. These findings highlight the importance of targeting individuals with heavy multimorbidity burden and promoting a heathy lifestyle to prevent cognitive impairment in Chinese older population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.