ArticleBMC pregnancy and childbirth2024
Ultrasonographic evaluation of the gallbladder motor function in the diagnosis and prognosis of intrahepatic cholestasis of pregnancy.
Article in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- The influence of serum sterol sulfotransferase, ANGPTL8, and SDC1 on liver function in patients with intrahepatic cholestasis during pregnancy.Journal of medical biochemistry · 2026Article
- The impact of gallbladder motility in intrahepatic cholestasis of pregnancy: a prospective observational study.Abdominal radiology (New York) · 2025Observational
- Ultrasound of the Gallbladder-An Update on Measurements, Reference Values, Variants and Frequent Pathologies: A Scoping Review.Life (Basel, Switzerland) · 2025Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIntrahepatic cholestasis of pregnancy (ICP) is characterized by skin pruritus, elevated liver enzymes, and increased serum total bile acids. Several previous studies have revealed that the fasting and ejection volumes of the gallbladder in cholestasis of pregnancy are greater than those in normal pregnancy. The goal of this study was to explore the gallbladder volume and evaluate the diagnostic and prognostic value of ultrasound in ICP.
methodsWe prospectively recruited a cohort of 60 ICP patients at the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China from January 2020 to December 2021 and compared their data with those from healthy pregnant women (n = 60). The gallbladder volume was evaluated by real-time ultrasound examination after overnight fasting and at 30, 60, 120, and 180 min after a liquid test meal of 200 mL, and the ejection fraction was calculated. Continuous data between two groups were compared by Student's t test. Differences were considered significant for p < 0.05. The diagnostic and prognostic value of the volume and ejection function of the gallbladder was analyzed by the receiver operating characteristic (ROC) curve.
resultsThe ICP group had significantly higher gallbladder basal volume (43.49 ± 1.34 cm
conclusionOur results indicate abnormal volume and ejection function of the gallbladder in patients with ICP. The ejection fraction at 120 min can assist in the diagnosis if ICP exists, and the gallbladder volume at 60 min may assess the degree of severity of ICP.
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