Evidence map›Paper›PMID 38166770›Full record

ArticleBMC public health2024

Effectiveness of health management team program to enhance prevention of mother-to-child transmission of hepatitis B virus in Ningxia, China.

Chenglei Zhang, Yongxiang Huang, Liying Ji, Qian Zhu, Lixin Wang, Jingjiao Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenglei ZhangMedical Laboratory, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750003, China.
Yongxiang HuangMedical Laboratory, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750003, China.
Liying JiDepartment of laboratory, Yinchuan women and children healthcare hospital, Yinchuan, Ningxia, 750001, China.
Qian ZhuMedical Laboratory, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750003, China.
Lixin WangMedical Laboratory, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750003, China.
Jingjiao WangDepartment of Periodontics, Stomatological Hospital, General Hospital of Ningxia Medical University, 804 Shengli South Street, Xingqing District, Yinchuan, Ningxia, 750003, China. weilan1029@163.com.

Funding

Key Research and Development Program of Ningxia, China 2019BEG03022
6 · The paper itself

Abstract

backgroundHepatitis B mother-to-child transmission interruption (PMTCT) poses a formidable challenge in underdeveloped regions of China. This study aims to evaluate the effectiveness of PMTCT and the health management team (HMT) model in Ningxia, China, as well as the risk factors for adverse outcomes.

methodsThe PMTCT + HMT model was established, and 360 pregnant women diagnosed with HBV infection in 2020-2022 were selected and divided into the control and the study groups based on different intervention modes. HBV serum markers and HBV DNA levels were assessed, the indicators of compliance behaviors and adverse outcomes were compared, and the factors influencing adverse outcomes were analyzed.

resultsThe majority of subjects were residents of the local city, married, with secondary school or higher education, and employees of public sectors. The proportion of ethnic minorities was 40.8% and 34.2% in the control group and study group. HBeAg positivity was 23.3% and 26.3%, and the proportion with HBV DNA levels ≥ 2 × 105 IU/mL was 9.2% and 7.1%. Compared with the control group (PMTCT alone), the PMTCT + HMT model led to improved maternal knowledge (17.5% vs. 57.1%), voluntary counseling (34.2% vs. 63.3%), and testing (37.5% vs. 70.4%). The incidence of adverse pregnancy outcomes ((including miscarriage, preterm birth) decreased significantly (17.5% vs. 6.2%), as did adverse neonatal outcomes (low birth weight and congenital HBV) (26.9% vs. 10.5%). Adverse outcomes were associated with low educational attainment, non-locals, unmarried status, and ethnic minority identity. Additionally, HBeAg positivity and HBV DNA levels ≥ 2 × 10

conclusionsThe PMTCT + HMT model demonstrates significant effectiveness in preventing mother-to-child transmission of hepatitis B in Ningxia. The unique demographic structure of Ningxia region is closely linked to poor outcomes, emphasizing the importance of monitoring HBeAg status and HBV DNA viral load level.

Indexed as

Hepatitis BPregnancy Complications, InfectiousPremature BirthChinaDNA, ViralEthnicityFemaleHepatitis B e AntigensHepatitis B Surface AntigensHepatitis B virusHumansInfant, NewbornInfectious Disease Transmission, VerticalMinority GroupsPregnancyDNA, ViralHepatitis B e AntigensHepatitis B Surface AntigensAdverse outcomesHealth management teamHepatitis BMother-to-child transmission interruption

Identifiers

PMID38166770
PMCPMC10763679

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.