Evidence map›Paper›PMID 38166769›Full record

Trial reportBMC gastroenterology2024

The effect of an acute aspirin challenge on intestinal permeability in healthy adults with and without prophylactic probiotic consumption: a double-blind, placebo-controlled, randomized trial.

Taylor C Judkins, Rebecca J Solch-Ottaiano, Brendan Ceretto-Clark, Carmelo Nieves, James Colee, Yu Wang, Thomas A Tompkins, Sara E Caballero-Calero, Bobbi Langkamp-Henken

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Taylor C JudkinsFood Science and Human Nutrition Department, University of Florida, 572 Newell Dr, Gainesville, FL, 32611, USA.
Rebecca J Solch-OttaianoFood Science and Human Nutrition Department, University of Florida, 572 Newell Dr, Gainesville, FL, 32611, USA.
Brendan Ceretto-ClarkFood Science and Human Nutrition Department, University of Florida, 572 Newell Dr, Gainesville, FL, 32611, USA.
Carmelo NievesFood Science and Human Nutrition Department, University of Florida, 572 Newell Dr, Gainesville, FL, 32611, USA.
James ColeeIFAS Statistical Consulting Unit, University of Florida, PO Box 110500, Gainesville, FL, 32611-0500, USA.
Yu WangFood Science and Human Nutrition Department, University of Florida, 572 Newell Dr, Gainesville, FL, 32611, USA.
Thomas A TompkinsLallemand Bio-Ingredients, 1620 Rue Prefontaine, Montreal, QC, H1N 2W8, Canada.
Sara E Caballero-CaleroLallemand Health Solutions, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada.
Bobbi Langkamp-HenkenFood Science and Human Nutrition Department, University of Florida, 572 Newell Dr, Gainesville, FL, 32611, USA. henken@ufl.edu.
University of Florida · USLallemand (Canada) · CAFlorida Department of Citrus · US

Funding

USDA National Institute of Food and Agriculture, Hatch project FLA-FOS-006391
6 · The paper itself

Abstract

backgroundHealthy individuals may experience increases in intestinal permeability after chronic or acute use of non-steroidal anti-inflammatory drugs, which may be attenuated by probiotics. This study investigates the effects of an acute aspirin challenge on gastroduodenal barrier function with or without prophylactic probiotic consumption.

methodsTwenty-nine generally healthy participants (26 ± 6 years) completed a 14-week randomized, double-blind, crossover trial. A probiotic containing 2 Lactobacilli strains or placebo was administered for 3 weeks, with a 4-week washout period between crossover phases. Daily and weekly questionnaires assessing gastrointestinal function were completed for 2 weeks before until 2 weeks after each intervention to assess gastrointestinal function. Gastroduodenal permeability was assessed by urinary excretion of orally administered sucrose after 1, 2, and 3 weeks of each intervention with a 1950 mg-aspirin challenge after 2 weeks of supplementation. Stool samples were collected weekly during supplementation for detection of species of interest.

resultsGastroduodenal permeability increased with aspirin challenge (Week 1: 3.4 ± 0.6 μmol vs Week 2: 9.9 ± 1.0 μmol urinary sucrose; p < 0.05). There were no differences in the change in permeability after the aspirin challenge or gastrointestinal function between interventions.

conclusionThe acute aspirin challenge significantly increased intestinal permeability similarly in both groups, and prophylactic probiotic consumption was unable to prevent the loss in this particular model.

Indexed as

AspirinProbioticsAdultAnti-Inflammatory Agents, Non-SteroidalDouble-Blind MethodHumansIntestinal Barrier FunctionSucroseAnti-Inflammatory Agents, Non-SteroidalAspirinSucroseGastrointestinal healthIntestinal permeabilityNSAIDProbiotic

Identifiers

PMID38166769
PMCPMC10759586
OpenAlexW4390501851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.