Evidence map›Paper›PMID 38166565›Full record

ArticleBMC genomics2024

A preliminary exploration on the mechanism of the carbapenem-resistance transformation of Serratia marcescens in vivo.

Qian Xu, Beiwen Zheng, Kaixuan Li, Ping Shen, Yonghong Xiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Plasmid diversity ofMicrobiology spectrum · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Qian XuLaboratory Medicine Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Beiwen ZhengState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, National Clinical Research Center for Infectious Diseases, Zhejiang University, NO.79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, China.
Kaixuan LiLaboratory Medicine Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Ping ShenState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, National Clinical Research Center for Infectious Diseases, Zhejiang University, NO.79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, China.
Yonghong XiaoState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, National Clinical Research Center for Infectious Diseases, Zhejiang University, NO.79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, China. xiaoyonghong@zju.edu.cn.
State Key Laboratory of Diagnosis and Treatment of Infectious DiseasesZhejiang Provincial People's Hospital · CNZhejiang University · CN

Funding

Fundamental Research Funds for the Central Universities 2022ZFJH003National Key Research and Development Program of China 2021YFC2300300Natural Science Foundation of Zhejiang Province LQ22H190004
6 · The paper itself

Abstract

backgroundThe infection of carbapenem-resistant organisms was a huge threat to human health due to their global spread. Dealing with a carbapenem-resistant Serratia marcescens (CRSM) infection poses a significant challenge in clinical settings. This study aims to provide insights into strategies for controlling CRSM infection by exploring the transformation mechanism of carbapenem-resistance.

methodsWe used whole genome sequencing (WGS) to investigate the mechanism of carbapenem resistance in 14 S. marcescens isolates in vivo. The expression level of related genes and the minimum inhibitory concentration of meropenem (MIC

resultsSeven groups of S. marcescens, each consisting of two strains, were collected from a hospital and displayed a shift in MIC

conclusionThe study findings suggest that S. marcescens strains developed diverse carbapenem resistance in vivo through the evolution of drug resistance, rather than through clone replacement. We hypothesize that carbapenem resistance in S. marcescens was due to certain clonal types with a distinct mechanism.

Indexed as

CarbapenemsSerratia marcescensAnti-Bacterial Agentsbeta-LactamasesHumansMeropenemMicrobial Sensitivity TestsAnti-Bacterial Agentsbeta-LactamasesCarbapenemsMeropenembla KPCCarbapenem-resistanceSerratia marcescens

Identifiers

PMID38166565
PMCPMC10759614
OpenAlexW4390506276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.