ArticlePloS one2024
Alpha-1 antitrypsin deficiency and pregnancy complications and birth outcomes: A population-based cohort study in Denmark.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- AAT/SERPINA1 Pi*Z variant linked to gestational length and preterm birth prevention via AAT in mice.Nature communications · 2026Article
- Carrier screening in the reproductive setting-Are there medical implications for the heterozygote?-A guide for clinicians.Pregnancy (Hoboken, N.J.) · 2026Review
- Modulation of Immune Cells by Aspirin During Pregnancy.Immunology · 2026Observational
- Complications Following Late Second-Trimester Dilatation and Evacuation: A Retrospective Cohort Comparison of Missed and Induced Abortions.International journal of women's health · 2026Article
- Maternal serum alpha-1 antitrypsin levels in spontaneous preterm and term pregnancies.Scientific reports · 2024Article
- Alpha-1 antitripsyn deficiency and augmentation therapy in pregnancy: two case reports.Frontiers in medicine · 2024Article
- Article
- Successful Obstetric Outcome in a Woman with Prior Kasai Procedure for Biliary Atresia and Concurrent Alpha-1 Antitrypsin Deficiency: A Case Report.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlpha-1 antitrypsin deficiency (AATD) is related to developing lung and liver disease, but no large-scale studies examine its association with birth outcomes.
objectiveWe investigated the risk of pregnancy complications and adverse birth outcomes in mothers and children with AATD.
methodsUsing a large cohort data of Danish mothers and children with AATD from 1973 to 2013 (n = 2,027,229), with 559 cases (305 mothers and 254 children). We conducted Poisson regression to examine associations between alpha-1 antitrypsin deficiency, adverse birth outcomes, and pregnancy complications in mothers and children.
resultsAATD was related to term low birth weight [<2500g; Risk Ratio(RR) = 2.04, 95% confidence interval (CI): 1.50-2.79], lowest quartile of abdominal circumference at birth in children of non-smoking mothers (RR = 1.55, 95% CI: 1.14-2.11), delivery via Cesarean-section (RR = 1.59, 95% CI: 1.05-2.40), preterm birth (RR = 1.54, 95% CI: 1.19-2.00) and preeclampsia (RR = 2.64, 95% CI: 1.76-3.94).
conclusionsThis emphasizes the need for mothers with AATD to be monitored closely during pregnancy to reduce the risk of adverse birth outcomes. Routine screening for alpha-1 antitrypsin in pregnancy may be considered among mothers with a pulmonary and liver disease history.
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