Evidence map›Paper›PMID 38166049›Full record

ArticlePloS one2024

Real-world evaluation of care for type 2 diabetes in Malaysia: A cross-sectional analysis of the treatment adherence to guideline evaluation in type 2 diabetes (TARGET-T2D) study.

Lee-Ling Lim, Zanariah Hussein, Nurain Md Noor, Anis S Abd Raof, Norlaila Mustafa, Mohamed B Long Bidin, Rohana Abdul Ghani, Syahrizan Samsuddin, Sy-Liang Yong, Siew-Hui Foo and 5 more

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Hypertension in Adults With Diabetes in Southeast Asia: A Systematic Review.Journal of clinical hypertension (Greenwich, Conn.) · 2025
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Intention of smartphone application usage in diabetes self-management and its associated factors among patients with diabetes: A cross-sectional study.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lee-Ling LimFaculty of Medicine, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.ORCID 0000-0002-6214-6924
Zanariah HusseinDepartment of Medicine, Hospital Putrajaya, Putrajaya, Malaysia.
Nurain Md NoorDepartment of Medicine, Hospital Putrajaya, Putrajaya, Malaysia.
Anis S Abd RaofFaculty of Medicine, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.ORCID 0000-0002-4500-2857
Norlaila MustafaFaculty of Medicine, Department of Medicine, Universiti Kebangsaan Malaysia, Selangor, Malaysia.
Mohamed B Long BidinDepartment of Medicine, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Rohana Abdul GhaniFaculty of Medicine, Department of Medicine, Universiti Teknologi MARA, Selangor, Malaysia.
Syahrizan SamsuddinDepartment of Medicine, Hospital Serdang, Selangor, Malaysia.
Sy-Liang YongDepartment of Medicine, Hospital Tengku Ampuan Rahimah, Selangor, Malaysia.
Siew-Hui FooDepartment of Medicine, Hospital Selayang, Selangor, Malaysia.ORCID 0000-0002-5635-4508
Kavitha RaghuramBoehringer Ingelheim Singapore Pte. Ltd, Singapore.
Payiarat SuwannasriBoehringer Ingelheim Singapore Pte. Ltd, Singapore.
Wan Mohamad W BSchool of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Thiam-Kian ChiewFaculty of Computer Science and Information Technology, Department of Software Engineering, University of Malaya, Kuala Lumpur, Malaysia.
Siew-Pheng ChanFaculty of Medicine, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimGiven a lack of data on diabetes care performance in Malaysia, we conducted a cross-sectional study to understand the clinical characteristics, control of cardiometabolic risk factors, and patterns of use of guideline-directed medical therapy (GDMT) among patients with type 2 diabetes (T2D), who were managed at publicly-funded hospitals between December 2021 and June 2022.

methodsPatients aged ≥18 years with T2D from eight publicly-funded hospitals in the Greater Kuala Lumpur region, who had ≥2 outpatient visits within the preceding year and irrespective of treatment regimen, were eligible. The primary outcome was ≥2 treatment target attainment (defined as either HbA1c <7.0%, blood pressure [BP] <130/80 mmHg, or low-density lipoprotein cholesterol [LDL-C] <1.8 mmol/L). The secondary outcomes were the individual treatment target, a combination of all three treatment targets, and patterns of GDMT use. To assess for potential heterogeneity of study findings, all outcomes were stratified according to prespecified baseline characteristics namely 1) history of atherosclerotic cardiovascular disease (ASCVD; yes/no) and 2) clinic type (Diabetes specialist versus General medicine).

resultsAmong 5094 patients (mean±SD age 59.0±13.2 years; T2D duration 14.8±9.2 years; HbA1c 8.2±1.9% (66±21 mmol/mol); BMI 29.6±6.2 kg/m2; 45.6% men), 99% were at high/very high cardiorenal risk. Attainment of ≥2 treatment targets was at 18%, being higher in General medicine than in Diabetes specialist clinics (20.8% versus 17.5%; p = 0.039). The overall statin coverage was 90%. More patients with prior ASCVD attained LDL-C <1.4 mmol/L than those without (13.5% versus 8.4%; p<0.001). Use of sodium-glucose cotransporter-2 (SGLT2) inhibitors (13.2% versus 43.2%), glucagon-like peptide-1 receptor agonists (GLP1-RAs) (1.0% versus 6.2%), and insulin (27.7% versus 58.1%) were lower in General medicine than in Diabetes specialist clinics.

conclusionsAmong high-risk patients with T2D, treatment target attainment and use of GDMT were suboptimal.

Indexed as

Diabetes Mellitus, Type 2AdolescentAdultAgedCholesterol, LDLCross-Sectional StudiesFemaleGlycated HemoglobinHumansMalaysiaMaleMiddle AgedTreatment Adherence and ComplianceCholesterol, LDLGlycated Hemoglobin

Identifiers

PMID38166049
PMCPMC10760741

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.