Evidence map›Paper›PMID 38166044›Full record

ArticlePloS one2024

Factors influencing the uptake of a mono-PrEP implant for the prevention of HIV: Males' perspectives from three South African provinces.

Nqaba Mthimkhulu, Glory Chidumwa, Alison Kutywayo, Paballo Mataboge, Catherine E Martin, Khanyiswa Kwatsha, Nthabiseng Makalela, Mbali Mazibuko, Vusile Butler, Saiqa Mullick

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nqaba MthimkhuluWits RHI, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0001-5870-8851
Glory ChidumwaWits RHI, University of the Witwatersrand, Johannesburg, South Africa.
Alison KutywayoWits RHI, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0001-5545-7030
Paballo MatabogeWits RHI, University of the Witwatersrand, Johannesburg, South Africa.
Catherine E MartinWits RHI, University of the Witwatersrand, Johannesburg, South Africa.
Khanyiswa KwatshaWits RHI, University of the Witwatersrand, Johannesburg, South Africa.
Nthabiseng MakalelaWits RHI, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0009-0001-8427-1822
Mbali MazibukoWits RHI, University of the Witwatersrand, Johannesburg, South Africa.
Vusile ButlerWits RHI, University of the Witwatersrand, Johannesburg, South Africa.
Saiqa MullickWits RHI, University of the Witwatersrand, Johannesburg, South Africa.
University of the Witwatersrand · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOral pre-exposure prophylaxis (PrEP) is an effective HIV prevention method; however, males over 15 years face challenges with its effective use. Long-acting prevention products could address barriers to effective PrEP use. This study aimed to estimate the potential uptake of a mono-PrEP implant and the factors influencing uptake among males in South Africa. The study also examined messaging and demand creation tactics that males perceive will improve HIV prevention uptake.

methodsWe conducted a mixed methods study comprising participatory workshops and a self-administered survey among 142 PrEP-eligible males (18-40 years) in three provinces (Gauteng, Eastern Cape, and Kwa-Zulu Natal) in South Africa from July to November 2022. Logistic regression was used to assess the relationship between the potential uptake of a hypothetical, non-biodegradable mono-PrEP implant and socioeconomic and behavioural factors. Workshop data were analysed using content analysis.

resultsThe top three HIV prevention products that males would consider using were the monthly pill (74.6%), the mono-PrEP implant (62.7%), and event-driven oral PrEP (59.2%). If one prevention option was available, 31.7% of participants stated that they would use the monthly oral pill, 28.2% would use the six-monthly injection, and 19.7% the mono-PrEP implant. Four key themes were noted as influential to potential mono-PrEP uptake: "Health Over Everything", "Mono-PrEP Implant Concerns", "Potential Disclosure of Mono-PrEP Use", and "Information Distribution Channels". Participants preferred social and mainstream media as information distribution channels to receive information on HIV prevention services, including the mono-PrEP implant.

conclusionIn this study among predominantly heterosexual men in South Africa, there was interest in long-acting HIV prevention methods but concerns about the mono-PrEP implant. A comprehensive and participatory introduction will be needed for the implant, to improve acceptability and address potential concerns. Demand-creation strategies utilising social media and health campaigns should be considered to engage and reach males.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisHeterosexualityHumansInjectionsMaleSouth AfricaAnti-HIV Agents

Identifiers

PMID38166044
PMCPMC10760848
OpenAlexW4390496146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.