ArticleProceedings of the National Academy of Sciences of the United States of America2024
Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Random Forest Modeling to Predict Small Molecule Accumulation in Gram-Negative Bacteria.ACS infectious diseases · 2026Article
- Review
- Construction of a Subcutaneous Fat Transplantation Model Infected with Mycobacterium.Current medicinal chemistry · 2026Article
- Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus.Nature microbiology · 2025Article
- Macrolide resistance inJAC-antimicrobial resistance · 2025Review
- Development of tetracycline analogues with increased aqueous stability for the treatment of mycobacterial infections.Tuberculosis (Edinburgh, Scotland) · 2025Article
- Activity of combinations of bactericidal and bacteriostatic compounds inFrontiers in microbiology · 2025Review
- Toward better cures forClinical microbiology reviews · 2024Review
- Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.The Journal of antibiotics · 2024Article
- The diversity of clinicalJournal of medical microbiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 4 institutions in 2 countries.
Gregory A Phelps *Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0001-5862-5212
Martin N Cheramie *Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
Dinesh M FernandoDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
Petra SelchowInstitute of Medical Microbiology, University of Zurich, Zurich CH-8006, Switzerland.ORCID 0000-0001-8305-3316
Christopher J MeyerDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
Samanthi L WaidyarachchiDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0009-0004-0090-7291
Suresh DharumanDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0002-5491-6677
Jiuyu LiuDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0002-0102-6590
Michael MeuliInstitute of Medical Microbiology, University of Zurich, Zurich CH-8006, Switzerland.ORCID 0000-0002-8998-1698
Michael Dal MolinInstitute of Medical Microbiology, University of Zurich, Zurich CH-8006, Switzerland.
Benjamin Y KillamDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607.ORCID 0000-0002-7774-9648
Patricia A MurphyDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
Stephanie M ReeveDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
Laura A WiltDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0001-5723-1692
Shelby M AndersonDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0003-4135-5951
Lei YangDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0002-3060-0790
Robin B LeeDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
Zaid H TemrikarDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163.
Pradeep B LukkaDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163.
Bernd MeibohmDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163.ORCID 0000-0003-3923-3648
Yury S PolikanovDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607.ORCID 0000-0002-5064-0327
Sven N HobbieInstitute of Medical Microbiology, University of Zurich, Zurich CH-8006, Switzerland.ORCID 0000-0002-9205-0384
Erik C BöttgerInstitute of Medical Microbiology, University of Zurich, Zurich CH-8006, Switzerland.ORCID 0000-0002-2570-0121
Peter SanderInstitute of Medical Microbiology, University of Zurich, Zurich CH-8006, Switzerland.ORCID 0000-0003-1581-0682
Richard E LeeDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0002-2397-0443
St. Jude Children's Research Hospital · USUniversity of Zurich · CHUniversity of Tennessee Health Science Center · USUniversity of Illinois Chicago · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MUser Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI MALCOLM S. CAPEL · 2018 to 2026
$34.2MSpectinomycin analogs for NTM infectionsR01AI157312 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI LEE, RICHARD E. · 2020 to 2024
$4.1MTraining in the Design and Development of Infectious Disease TherapeuticsT32AI106700 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Richard E. Lee · 2015 to 2026
$2.1MPixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0MMolecular mechanisms of action of ribosome-targeting antibiotics.R01GM132302 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI POLIKANOV, YURY · 2019 to 2022
$1.3MTofacitinib Analogs as Oxacillin Potentiators against MRSAF31AI169961 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC · PI PHELPS, GREGORY A · 2023 to 2024
$80kNCI NIH HHS P30 CA021765NIAID NIH HHS F31 AI169961NIAID NIH HHS HHSN272201100009CNIAID NIH HHS R01 AI157312NIAID NIH HHS T32 AI106700NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM132302NIH HHS S10 OD021527
Abstract
PubMed holds no abstract for this paper.
Indexed as
Anti-Infective AgentsMycobacterium abscessusMycobacterium Infections, NontuberculousAnimalsAnti-Bacterial AgentsEthylenesHumansMiceMicrobial Sensitivity TestsNontuberculous MycobacteriaSpectinomycinAnti-Bacterial AgentsAnti-Infective AgentsEthylenesSpectinomycinantibioticantimicrobial resistanceeffluxnontuberculous mycobacteriaprotein synthesis inhibitor
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.