Evidence map›Paper›PMID 38165577›Full record

ArticleCerebellum (London, England)2024

Knockdown of the Non-canonical Wnt Gene Prickle2 Leads to Cerebellar Purkinje Cell Abnormalities While Cerebellar-Mediated Behaviors Remain Intact.

Parker W Abbott, Jason B Hardie, Kyle P Walsh, Aaron J Nessler, Sean J Farley, John H Freeman, John A Wemmie, Linder Wendt, Young-Cho Kim, Levi P Sowers and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebellum (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Deletion of the Voltage-Gated Calcium Channel Gene, CaCerebellum (London, England) · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Parker W AbbottDepartment of Psychiatry, Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52242, USA.
Jason B HardieDepartment of Psychiatry, Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52242, USA.
Kyle P WalshDepartment of Psychiatry, Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52242, USA.
Aaron J NesslerDepartment of Biochemistry, The University of Iowa, Iowa City, IA, 52245, USA.
Sean J FarleyThe University of Iowa, Iowa City, IA, 52242, USA.
John H FreemanDepartment of Psychiatry, Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52242, USA.
John A WemmieDepartment of Psychiatry, Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52242, USA.
Linder WendtDepartment of Biostatistics, The University of Iowa, Iowa City, IA, 52245, USA.
Young-Cho KimIowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52245, USA.
Levi P SowersIowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52245, USA.
Krystal L ParkerDepartment of Psychiatry, Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52242, USA. krystal-parker@uiowa.edu.
University of Iowa · US

Funding

University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI EDWIN TED G. ABEL, Lane Strathearn · 2021 to 2026
$8.5M
Cerebellar circuits, timing, and cognitionR01MH118240 · NIMH · UNIVERSITY OF IOWA · PI PARKER, KRYSTAL LYNN · 2019 to 2023
$2.2M
BLRD VA I01 BX004440NICHD NIH HHS P50 HD103556NIMH NIH HHS R01 MH118240
6 · The paper itself

Abstract

Autism spectrum disorders (ASD) involve brain wide abnormalities that contribute to a constellation of symptoms including behavioral inflexibility, cognitive dysfunction, learning impairments, altered social interactions, and perceptive time difficulties. Although a single genetic variation does not cause ASD, genetic variations such as one involving a non-canonical Wnt signaling gene, Prickle2, has been found in individuals with ASD. Previous work looking into phenotypes of Prickle2 knock-out (Prickle2

Indexed as

CerebellumLIM Domain ProteinsPurkinje CellsAnimalsBehavior, AnimalDisease Models, AnimalGene Knockdown TechniquesMaleMiceMice, Inbred C57BLMice, KnockoutLIM Domain ProteinsAutism spectrum disordersCerebellumCognitionPurkinje cellsWnt signaling

Identifiers

PMID38165577
PMCPMC11217148
OpenAlexW4390506096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.