Evidence map›Paper›PMID 38165573›Full record

ArticleJournal of molecular histology2024

Knockout of KDM3A in MDA-MB-231 breast cancer cells inhibits tumor malignancy and promotes apoptosis.

Yuanxing Han, Nueryemu Maimaiti, Yue Sun, Juan Yao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular histology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yuanxing HanThe First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830000, China.
Nueryemu MaimaitiThe First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830000, China.
Yue SunThe First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830000, China.
Juan YaoThe First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830000, China. yaoj324@163.com.
Xinjiang Medical University · CNFirst Affiliated Hospital of Xinjiang Medical University · CN

Funding

National Natural Science Foundation of China 81660305
6 · The paper itself

Abstract

The histone lysine demethylase 3 A (KDM3A) is vital for the regulation of cancer physiology and pathophysiology. The purpose of this study was to investigate the effect of KDM3A expression with triple-negative breast cancer (TNBC) invasion and metastasis. In our results, knockout of KDM3A in TNBC MDA-MB-231 cells promoted apoptosis and inhibited the proliferation, invasion and metastasis of MDA-MB-231 cells. In addition, we found that in vivo experiments indicated that the growth, invasion and metastasis of metastatic neoplasms were significantly inhibited by knockout of KDM3A in a TNBC metastasis model. These findings suggest that KDM3A may be a potential therapeutic target for the treatment and prevention of TNBC, providing a critical theoretical basis for the effective prevention or treatment of breast cancer disease.

Indexed as

Triple Negative Breast NeoplasmsApoptosisCell Line, TumorCell ProliferationHumansJumonji Domain-Containing Histone DemethylasesMDA-MB-231 CellsJumonji Domain-Containing Histone DemethylasesKDM3A protein, humanBreast cancerKDM3ALysine demethylase 3AMetastases

Identifiers

PMID38165573
PMCPMC10830655
OpenAlexW4390496339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.