Evidence map›Paper›PMID 38165360›Full record

ArticleReproduction (Cambridge, England)2024

Does TFAP2C govern conflicting cell fates in mouse preimplantation embryos?

Chad S Driscoll, Jaehwan Kim, Mohamed Ashry, Jason G Knott

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproduction (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chad S DriscollDepartment of Animal Science, Developmental Epigenetics Laboratory, Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan, USA.
Jaehwan KimDepartment of Animal Science, Developmental Epigenetics Laboratory, Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan, USA.
Mohamed AshryDepartment of Animal Science, Developmental Epigenetics Laboratory, Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan, USA.
Jason G KnottDepartment of Animal Science, Developmental Epigenetics Laboratory, Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0003-1626-7933
Michigan State University · USUniversity of Missouri · US

Funding

Reproductive and Developmental Sciences Training Program - T32T32HD087166 · NICHD · MICHIGAN STATE UNIVERSITY · PI Ronald L Chandler, Keith E Latham · 2016 to 2026
$2.5M
Mechanisms of trophoblast lineage formation: Impact on postimplantation placental developmentR01HD095371 · NICHD · MICHIGAN STATE UNIVERSITY · PI KNOTT, JASON GLENN · 2018 to 2022
$1.6M
NICHD NIH HHS R01 HD095371NICHD NIH HHS T32 HD087166
6 · The paper itself

Abstract

Transcription factor AP2 gamma (TFAP2C) is a well-established regulator of the trophoblast lineage in mice and humans, but a handful of studies indicate that TFAP2C may play an important role in pluripotency. Here, we hypothesize and provide new evidence that TFAP2C functions as an activator of trophoblast and pluripotency genes during preimplantation embryo development.

Indexed as

BlastocystTranscription Factor AP-2AnimalsEmbryonic DevelopmentFemaleHumansMicePregnancyTrophoblastsTFAP2C protein, humanTfap2c protein, mouseTranscription Factor AP-2

Identifiers

PMID38165360
PMCPMC10967010
OpenAlexW4390507987

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.