ArticleNeurology2024
Association of Poor Oral Health With Neuroimaging Markers of White Matter Injury in Middle-Aged Participants in the UK Biobank.
Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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14 citing papers in PubMed, 12 citations in OpenAlex.
- Masticatory Dysfunction and Hippocampal Volume in Ageing Adults: An MRI-Based Scoping Review.Journal of oral rehabilitation · 2026Article
- Edentulism, blood-based neurodegenerative biomarkers, and 10-year dementia risk: A mediation analysis in a nationally representative United States cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Tooth loss is associated with subsequent brain white matter degradation up to over a decade.Journal of dentistry · 2026Article
- Spousal Dementia Exposure and Risk of Dementia.JAMA network open · 2026Article
- Article
- Denture use is associated with a higher risk of cholelithiasis: a prospective cohort study.BMC oral health · 2026Article
- Cognitive performance in adolescents with perinatally-acquired HIV and associations with oral health in Nigeria.AIDS (London, England) · 2026Article
- Oral Diseases and Brain Pathologies: A Systematic Review with Narrative Synthesis of Clinical, Neuroimaging, and Mechanistic Evidence.Biomedicines · 2026Review
- The association of estimated glucose disposal rate with white matter hyperintensities: A large prospective cohort study.The journal of prevention of Alzheimer's disease · 2026Article
- Oral frailty trajectories and influencing factors in older adults with stroke: a longitudinal study.BMC nursing · 2025Article
- Genomic structural equation modeling identifies shared genetic architecture and novel loci for halitosis.Scientific reports · 2025Article
- Alterations of the oral microbiota in mild Alzheimer's disease and the appropriate application of chlorhexidine gluconate.JAR life · 2025Article
- Tooth Loss in Periodontitis Patients-A Risk Factor for Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2024Review
- Corrections to Preprint Server Information.Neurology · 2024Article
Corrections and comments
- Commented on by
- Erratum issued
- Update of
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesPoor oral health is a modifiable risk factor that is associated with clinically observed cardiovascular disease. However, the relationship between oral and brain health is not well understood. We tested the hypothesis that poor oral health is associated with worse neuroimaging brain health profiles in middle-aged persons without stroke or dementia.
methodsWe performed a 2-stage cross-sectional neuroimaging study using UK Biobank data. First, we tested for association between self-reported poor oral health and MRI neuroimaging markers of brain health. Second, we used Mendelian randomization (MR) analyses to test for association between genetically determined poor oral health and the same neuroimaging markers. Poor oral health was defined as the presence of dentures or loose teeth. As instruments for the MR analysis, we used 116 independent DNA sequence variants linked to increased composite risk of dentures or teeth that are decayed, missing, or filled. Neuroimaging markers of brain health included white matter hyperintensity (WMH) volume and aggregate measures of fractional anisotropy (FA) and mean diffusivity (MD), 2 metrics indicative of white matter tract disintegrity obtained through diffusion tensor imaging across 48 brain regions.
resultsWe included 40,175 persons (mean age 55 years, female sex 53%) enrolled from 2006 to 2010, who underwent a dedicated research brain MRI between 2014 and 2016. Among participants, 5,470 (14%) had poor oral health. Poor oral health was associated with a 9% increase in WMH volume (β = 0.09, SD = 0.014, DISCUSSION: Among middle age Britons without stroke or dementia, poor oral health was associated with worse neuroimaging brain health profiles. Genetic analyses confirmed these associations, supporting a potentially causal association. Because the neuroimaging markers evaluated in this study precede and are established risk factors of stroke and dementia, our results suggest that oral health, an easily modifiable process, may be a promising target for very early interventions focused on improving brain health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.