Evidence map›Paper›PMID 38165272›Full record

ArticleAnalytical chemistry2024

Speeding-up the Determination of Protein-Ligand Affinities by STD NMR: The Reduced Data Set STD NMR Approach (rd-STD NMR).

Gabriel Rocha, Jonathan Ramírez-Cárdenas, M Carmen Padilla-Pérez, Samuel Walpole, Ridvan Nepravishta, M Isabel García-Moreno, Elena M Sánchez-Fernández, Carmen Ortiz Mellet, Jesús Angulo, Juan C Muñoz-García

Open access · hybridAbstract read
In one paragraph

Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Lignans inFrontiers in plant science · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Gabriel RochaInstitute for Chemical Research (IIQ), CSIC─University of Seville, 49 Américo Vespucio St, 41092 Seville, Spain.ORCID 0009-0004-5673-5943
Jonathan Ramírez-CárdenasInstitute for Chemical Research (IIQ), CSIC─University of Seville, 49 Américo Vespucio St, 41092 Seville, Spain.
M Carmen Padilla-PérezDepartment of Organic Chemistry, Faculty of Chemistry, University of Seville, 1 Prof. García González St, 41012 Seville, Spain.ORCID 0000-0002-1280-3623
Samuel WalpoleSchool of Pharmacy, University of East Anglia, Norwich Research Park, NR4 7TJ Norwich, United Kingdom.
Ridvan NepravishtaSchool of Pharmacy, University of East Anglia, Norwich Research Park, NR4 7TJ Norwich, United Kingdom.
M Isabel García-MorenoDepartment of Organic Chemistry, Faculty of Chemistry, University of Seville, 1 Prof. García González St, 41012 Seville, Spain.
Elena M Sánchez-FernándezDepartment of Organic Chemistry, Faculty of Chemistry, University of Seville, 1 Prof. García González St, 41012 Seville, Spain.
Carmen Ortiz MelletDepartment of Organic Chemistry, Faculty of Chemistry, University of Seville, 1 Prof. García González St, 41012 Seville, Spain.ORCID 0000-0002-7676-7721
Jesús AnguloInstitute for Chemical Research (IIQ), CSIC─University of Seville, 49 Américo Vespucio St, 41092 Seville, Spain.ORCID 0000-0001-7250-5639
Juan C Muñoz-GarcíaInstitute for Chemical Research (IIQ), CSIC─University of Seville, 49 Américo Vespucio St, 41092 Seville, Spain.ORCID 0000-0003-2246-3236
Universidad de Sevilla · ESInstituto de Investigaciones Químicas · ESUniversity of East Anglia · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STD NMR spectroscopy is a powerful ligand-observed NMR tool for screening and characterizing the interactions of small molecules and low molecular weight fragments with a given macromolecule, identifying the main intermolecular contacts in the bound state. It is also a powerful analytical technique for the accurate determination of protein-ligand dissociation constants (

Indexed as

Magnetic Resonance ImagingProteinsEpitope MappingLigandsMagnetic Resonance SpectroscopyProtein BindingLigandsProteins

Identifiers

PMID38165272
PMCPMC10853903
OpenAlexW4390501776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.