Evidence map›Paper›PMID 38165250›Full record

ArticleRadiology2024

Radiologic Features of Nodules Attached to the Mediastinal or Diaphragmatic Pleura at Low-Dose CT for Lung Cancer Screening.

Yeqing Zhu, Rowena Yip, Jiafang Zhang, Qiang Cai, Qi Sun, Pengfei Li, Natela Paksashvili, Natthaya Triphuridet, Claudia I Henschke, David F Yankelevitz and 3 more

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Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 20 institutions in 9 countries.

Yeqing ZhuFrom the Department of Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029 (Y.Z., R.Y., J.Z., Q.C., Q.S., P.L., N.P., N.T., C.I.H., D.F.Y.); Department of Radiology, Shanxi Provincial People's Hospital, Taiyuan, China (Q.C.); Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, China (Q.S., P.L.); and Department of Pulmonary Medicine, Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand (N.T.).ORCID 0000-0003-0593-5553
Rowena YipFrom the Department of Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029 (Y.Z., R.Y., J.Z., Q.C., Q.S., P.L., N.P., N.T., C.I.H., D.F.Y.); Department of Radiology, Shanxi Provincial People's Hospital, Taiyuan, China (Q.C.); Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, China (Q.S., P.L.); and Department of Pulmonary Medicine, Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand (N.T.).ORCID 0000-0002-6208-2780
Jiafang ZhangFrom the Department of Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029 (Y.Z., R.Y., J.Z., Q.C., Q.S., P.L., N.P., N.T., C.I.H., D.F.Y.); Department of Radiology, Shanxi Provincial People's Hospital, Taiyuan, China (Q.C.); Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, China (Q.S., P.L.); and Department of Pulmonary Medicine, Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand (N.T.).ORCID 0009-0006-9622-6603
Qiang CaiFrom the Department of Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029 (Y.Z., R.Y., J.Z., Q.C., Q.S., P.L., N.P., N.T., C.I.H., D.F.Y.); Department of Radiology, Shanxi Provincial People's Hospital, Taiyuan, China (Q.C.); Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, China (Q.S., P.L.); and Department of Pulmonary Medicine, Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand (N.T.).ORCID 0000-0003-3055-666X
Qi SunFrom the Department of Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029 (Y.Z., R.Y., J.Z., Q.C., Q.S., P.L., N.P., N.T., C.I.H., D.F.Y.); Department of Radiology, Shanxi Provincial People's Hospital, Taiyuan, China (Q.C.); Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, China (Q.S., P.L.); and Department of Pulmonary Medicine, Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand (N.T.).ORCID 0000-0003-2312-7613
Pengfei LiFrom the Department of Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029 (Y.Z., R.Y., J.Z., Q.C., Q.S., P.L., N.P., N.T., C.I.H., D.F.Y.); Department of Radiology, Shanxi Provincial People's Hospital, Taiyuan, China (Q.C.); Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, China (Q.S., P.L.); and Department of Pulmonary Medicine, Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand (N.T.).ORCID 0009-0003-5819-3853
Natela PaksashviliFrom the Department of Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029 (Y.Z., R.Y., J.Z., Q.C., Q.S., P.L., N.P., N.T., C.I.H., D.F.Y.); Department of Radiology, Shanxi Provincial People's Hospital, Taiyuan, China (Q.C.); Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, China (Q.S., P.L.); and Department of Pulmonary Medicine, Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand (N.T.).ORCID 0000-0001-7549-5077
Natthaya TriphuridetFrom the Department of Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029 (Y.Z., R.Y., J.Z., Q.C., Q.S., P.L., N.P., N.T., C.I.H., D.F.Y.); Department of Radiology, Shanxi Provincial People's Hospital, Taiyuan, China (Q.C.); Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, China (Q.S., P.L.); and Department of Pulmonary Medicine, Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand (N.T.).
Claudia I HenschkeFrom the Department of Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029 (Y.Z., R.Y., J.Z., Q.C., Q.S., P.L., N.P., N.T., C.I.H., D.F.Y.); Department of Radiology, Shanxi Provincial People's Hospital, Taiyuan, China (Q.C.); Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, China (Q.S., P.L.); and Department of Pulmonary Medicine, Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand (N.T.).ORCID 0000-0002-6085-5305
David F YankelevitzFrom the Department of Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029 (Y.Z., R.Y., J.Z., Q.C., Q.S., P.L., N.P., N.T., C.I.H., D.F.Y.); Department of Radiology, Shanxi Provincial People's Hospital, Taiyuan, China (Q.C.); Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, China (Q.S., P.L.); and Department of Pulmonary Medicine, Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand (N.T.).ORCID 0000-0001-7364-4294
Investigators of the International Early Lung Cancer Action Program and Initiative for Early Lung Cancer Research on Treatment–Mount Sinai Health SystemFrom the Department of Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029 (Y.Z., R.Y., J.Z., Q.C., Q.S., P.L., N.P., N.T., C.I.H., D.F.Y.); Department of Radiology, Shanxi Provincial People's Hospital, Taiyuan, China (Q.C.); Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, China (Q.S., P.L.); and Department of Pulmonary Medicine, Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand (N.T.).
Investigators of the International Early Lung Cancer Action Program
Investigators of the Initiative for Early Lung Cancer Research on Treatment–Mount Sinai Health System
Icahn School of Medicine at Mount Sinai · USClinical Trial Investigators · USHarbin Medical University · CNThe Coordinating Center · USCornell University · USState University of New York · USColumbia University Irving Medical Center · USClinica Universidad de Navarra · ESRoswell Park Comprehensive Cancer Center · USAzumi Hospital · JPCity Of Hope National Medical Center · USGastroZentrum Hirslanden Zürich · CHGood Samaritan Hospital · USGuthrie Foundation · USIRCCS Humanitas Research Hospital · ITLung Institute · USNorthwell Health · USQueens College, CUNY · USRegional Cancer Center · USRush University · US

Funding

Growth Assessment of Pulmonary NodulesR01CA078905 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI YANKELEVITZ, DAVID F · 1999 to 2007
$2.2M
NCI NIH HHS R01 CA078905
6 · The paper itself

Abstract

Background Pulmonary noncalcified nodules (NCNs) attached to the fissural or costal pleura with smooth margins and triangular or lentiform, oval, or semicircular (LOS) shapes at low-dose CT are recommended for annual follow-up instead of immediate workup. Purpose To determine whether management of mediastinal or diaphragmatic pleura-attached NCNs (M/DP-NCNs) with the same features as fissural or costal pleura-attached NCNs at low-dose CT can follow the same recommendations. Materials and Methods This retrospective study reviewed chest CT examinations in participants from two databases. Group A included 1451 participants who had lung cancer that was first present as a solid nodule with an average diameter of 3.0-30.0 mm. Group B included 345 consecutive participants from a lung cancer screening program who had at least one solid nodule with a diameter of 3.0-30.0 mm at baseline CT and underwent at least three follow-up CT examinations. Radiologists reviewed CT images to identify solid M/DP-NCNs, defined as nodules 0 mm in distance from the mediastinal or diaphragmatic pleura, and recorded average diameter, margin, and shape. General descriptive statistics were used. Results Among the 1451 participants with lung cancer in group A, 163 participants (median age, 68 years [IQR, 61.5-75.0 years]; 92 male participants) had 164 malignant M/DP-NCNs 3.0-30.0 mm in average diameter. None of the 164 malignant M/DP-NCNs had smooth margins and triangular or LOS shapes (upper limit of 95% CI of proportion, 0.02). Among the 345 consecutive screening participants in group B, 146 participants (median age, 65 years [IQR, 59-71 years]; 81 female participants) had 240 M/DP-NCNs with average diameter 3.0-30.0 mm. None of the M/DP-NCNs with smooth margins and triangular or LOS shapes were malignant after a median follow-up of 57.8 months (IQR, 46.3-68.1 months). Conclusion For solid M/DP-NCNs with smooth margins and triangular or LOS shapes at low-dose CT, the risk of lung cancer is extremely low, which supports the recommendation of Lung Imaging Reporting and Data System version 2022 for annual follow-up instead of immediate workup. © RSNA, 2024 See also the editorial by Goodman and Baruah in this issue.

Indexed as

Lung NeoplasmsMultiple Pulmonary NodulesAgedEarly Detection of CancerFemaleHumansMalePleuraRetrospective StudiesTomography, X-Ray Computed

Identifiers

PMID38165250
PMCPMC10831475
OpenAlexW4390508192

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.