ArticleRadiology2024
Quantification of Emphysema Progression at CT Using Simultaneous Volume, Noise, and Bias Lung Density Correction.
Open access · greenAbstract readMulticenter Study
In one paragraph
Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- The Use of Computed Tomography Densitometry for the Assessment of Emphysema in Clinical Trials: A Position Paper from the Fleischner Society.American journal of respiratory and critical care medicine · 2025Pooled it
- Signal, not noise: learning to measure emphysema beyond the -950 HU threshold.European radiology · 2026Article
- Segmentation-based deep learning emphysema quantification using chest CT: improved accuracy and robustness vs LAA-950.European radiology · 2026Article
- Radiomics and anaesthetic planning: Quantitative imaging as a new frontier in preoperative risk assessment.World journal of radiology · 2026Review
- Characterizing chronic obstructive pulmonary disease using quantitative MRI biomarkers.The British journal of radiology · 2026Review
- Multi-trait polygenic scores for COPD and COPD exacerbations implicate druggable proteins.JCI insight · 2026Article
- Precise Lung Density Quantification with a Physics-based CT Harmonizer.Radiology. Cardiothoracic imaging · 2026Observational
- Opportunistic Screening on Chest CT, From theAJR. American journal of roentgenology · 2026Review
- Influence of CT harmonization in longitudinal radiomics for NSCLC immunotherapy response prediction.Computers in biology and medicine · 2026Article
- A self-supervised framework for emphysema anomaly detection and staging in computed tomography scans.Patterns (New York, N.Y.) · 2026Article
- Reliability and Agreement of Quantitative Pulmonary Imaging Biomarkers Between Ultra-Low-Dose and Low-Dose Chest CT: A Paired Intra-Individual Study.Diagnostics (Basel, Switzerland) · 2026Article
- Reproducibility of lung density quantification across photon-counting and conventional energy-integrating CT: a comparative study.The British journal of radiology · 2025Article
- Uncertainty-aware quantitative CT evaluation of emphysema and mortality risk from variable radiation dose images.European radiology · 2025Article
- Post-COPD: Can Emphysema Be Repaired?American journal of respiratory and critical care medicine · 2025Article
- Effects of Intra-patient Lung Volume Variability on CT-Based Emphysema Quantification: A Virtual Imaging Study.Academic radiology · 2025Article
- Omic Risk Scores are Associated with COPD-related Traits Across Three Cohorts.medRxiv : the preprint server for health sciences · 2025Article
- Photon-counting detector CT provides superior subsolid nodule characterization compared to same-day energy-integrating detector CT.European radiology · 2025Article
- Association of Ground-Glass Opacities with Systemic Inflammation and Progression of Emphysema.American journal of respiratory and critical care medicine · 2024Article
- Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study.BMJ open respiratory research · 2024Article
- Development and Application of a Virtual Imaging Trial Framework for Longitudinal Quantification of Emphysema in CT.Proceedings of SPIE--the International Society for Optical Engineering · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Gonzalo Vegas Sánchez-FerreroFrom the Applied Chest Imaging Laboratory, Department of Radiology (G.V.S.F., R.S.J.E.), Applied Chest Imaging Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine (A.A.D., S.Y.A., G.R.W.), and Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine (E.K.S.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; and Division of Biostatistics and Bioinformatics (D.B., M.S.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (J.D.C.), and Department of Radiology (S.M.H., D.A.L.), National Jewish Health, Denver, Colo.ORCID 0000-0002-3803-4324
Alejandro A DíazFrom the Applied Chest Imaging Laboratory, Department of Radiology (G.V.S.F., R.S.J.E.), Applied Chest Imaging Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine (A.A.D., S.Y.A., G.R.W.), and Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine (E.K.S.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; and Division of Biostatistics and Bioinformatics (D.B., M.S.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (J.D.C.), and Department of Radiology (S.M.H., D.A.L.), National Jewish Health, Denver, Colo.ORCID 0000-0001-5037-2919
Samuel Y AshFrom the Applied Chest Imaging Laboratory, Department of Radiology (G.V.S.F., R.S.J.E.), Applied Chest Imaging Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine (A.A.D., S.Y.A., G.R.W.), and Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine (E.K.S.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; and Division of Biostatistics and Bioinformatics (D.B., M.S.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (J.D.C.), and Department of Radiology (S.M.H., D.A.L.), National Jewish Health, Denver, Colo.ORCID 0000-0003-0224-6939
David BaraghoshiFrom the Applied Chest Imaging Laboratory, Department of Radiology (G.V.S.F., R.S.J.E.), Applied Chest Imaging Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine (A.A.D., S.Y.A., G.R.W.), and Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine (E.K.S.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; and Division of Biostatistics and Bioinformatics (D.B., M.S.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (J.D.C.), and Department of Radiology (S.M.H., D.A.L.), National Jewish Health, Denver, Colo.ORCID 0000-0002-9485-9267
Matthew StrandFrom the Applied Chest Imaging Laboratory, Department of Radiology (G.V.S.F., R.S.J.E.), Applied Chest Imaging Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine (A.A.D., S.Y.A., G.R.W.), and Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine (E.K.S.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; and Division of Biostatistics and Bioinformatics (D.B., M.S.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (J.D.C.), and Department of Radiology (S.M.H., D.A.L.), National Jewish Health, Denver, Colo.ORCID 0000-0002-9083-5989
James D CrapoFrom the Applied Chest Imaging Laboratory, Department of Radiology (G.V.S.F., R.S.J.E.), Applied Chest Imaging Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine (A.A.D., S.Y.A., G.R.W.), and Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine (E.K.S.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; and Division of Biostatistics and Bioinformatics (D.B., M.S.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (J.D.C.), and Department of Radiology (S.M.H., D.A.L.), National Jewish Health, Denver, Colo.ORCID 0000-0002-1262-5230
Edwin K SilvermanFrom the Applied Chest Imaging Laboratory, Department of Radiology (G.V.S.F., R.S.J.E.), Applied Chest Imaging Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine (A.A.D., S.Y.A., G.R.W.), and Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine (E.K.S.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; and Division of Biostatistics and Bioinformatics (D.B., M.S.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (J.D.C.), and Department of Radiology (S.M.H., D.A.L.), National Jewish Health, Denver, Colo.ORCID 0000-0002-3641-3822
Stephen M HumphriesFrom the Applied Chest Imaging Laboratory, Department of Radiology (G.V.S.F., R.S.J.E.), Applied Chest Imaging Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine (A.A.D., S.Y.A., G.R.W.), and Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine (E.K.S.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; and Division of Biostatistics and Bioinformatics (D.B., M.S.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (J.D.C.), and Department of Radiology (S.M.H., D.A.L.), National Jewish Health, Denver, Colo.ORCID 0000-0002-5113-4530
George R WashkoFrom the Applied Chest Imaging Laboratory, Department of Radiology (G.V.S.F., R.S.J.E.), Applied Chest Imaging Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine (A.A.D., S.Y.A., G.R.W.), and Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine (E.K.S.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; and Division of Biostatistics and Bioinformatics (D.B., M.S.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (J.D.C.), and Department of Radiology (S.M.H., D.A.L.), National Jewish Health, Denver, Colo.
David A LynchFrom the Applied Chest Imaging Laboratory, Department of Radiology (G.V.S.F., R.S.J.E.), Applied Chest Imaging Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine (A.A.D., S.Y.A., G.R.W.), and Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine (E.K.S.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; and Division of Biostatistics and Bioinformatics (D.B., M.S.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (J.D.C.), and Department of Radiology (S.M.H., D.A.L.), National Jewish Health, Denver, Colo.ORCID 0000-0002-6329-2325
Raúl San José EstéparFrom the Applied Chest Imaging Laboratory, Department of Radiology (G.V.S.F., R.S.J.E.), Applied Chest Imaging Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine (A.A.D., S.Y.A., G.R.W.), and Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine (E.K.S.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; and Division of Biostatistics and Bioinformatics (D.B., M.S.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (J.D.C.), and Department of Radiology (S.M.H., D.A.L.), National Jewish Health, Denver, Colo.ORCID 0000-0002-3677-1996
Brigham and Women's Hospital · US
Funding
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MMetabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MPrognostic Markers of Emphysema ProgressionR01HL149877 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL · 2020 to 2023
$2.8MStatistical Standardization of CT for the Analysis of Parenchymal Injury Progression in SmokersK25HL143278 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI VEGAS SANCHEZ-FERRERO, GONZALO · 2019 to 2023
$935kCT and CXR Phenotyping Platform for Assessing COVID-19 Susceptibility and SeverityR21LM013670 · NLM · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL · 2021 to 2022
$428kRobust Detection of Early Small Airway DiseaseR21HL156229 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI VEGAS SANCHEZ-FERRERO, GONZALO · 2021 to 2022
$269kNHLBI NIH HHS K25 HL143278NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL149877NHLBI NIH HHS R21 HL156229NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NLM NIH HHS R21 LM013670
Abstract
Background CT attenuation is affected by lung volume, dosage, and scanner bias, leading to inaccurate emphysema progression measurements in multicenter studies. Purpose To develop and validate a method that simultaneously corrects volume, noise, and interscanner bias for lung density change estimation in emphysema progression at CT in a longitudinal multicenter study. Materials and Methods In this secondary analysis of the prospective Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study, lung function data were obtained from participants who completed baseline and 5-year follow-up visits from January 2008 to August 2017. CT emphysema progression was measured with volume-adjusted lung density (VALD) and compared with the joint volume-noise-bias-adjusted lung density (VNB-ALD). Reproducibility was studied under change of dosage protocol and scanner model with repeated acquisitions. Emphysema progression was visually scored in 102 randomly selected participants. A stratified analysis of clinical characteristics was performed that considered groups based on their combined lung density change measured by VALD and VNB-ALD. Results A total of 4954 COPDGene participants (mean age, 60 years ± 9 [SD]; 2511 male, 2443 female) were analyzed (1329 with repeated reduced-dose acquisition in the follow-up visit). Mean repeatability coefficients were 30 g/L ± 0.46 for VALD and 14 g/L ± 0.34 for VNB-ALD. VALD measurements showed no evidence of differences between nonprogressors and progressors (mean, -5.5 g/L ± 9.5 vs -8.6 g/L ± 9.6;
Indexed as
EmphysemaPulmonary EmphysemaFemaleHumansLungMaleMiddle AgedProspective StudiesReproducibility of ResultsTomography, X-Ray Computed
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