Evidence map›Paper›PMID 38165179›Full record

ArticleGut microbes

DSS treatment does not affect murine colonic microbiota in absence of the host.

Jannike Lea Krause, Beatrice Engelmann, Stephanie Serena Schaepe, Ulrike Rolle-Kampczyk, Nico Jehmlich, Hyun-Dong Chang, Ulla Slanina, Maximillian Hoffman, Jörg Lehmann, Ana Claudia Zenclussen and 3 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Targeted intestinal barrier repairActa pharmaceutica Sinica. B · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Immune microenvironment-dependent effects of age-associatedFrontiers in cellular and infection microbiology · 2025
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jannike Lea KrauseGerman Rheumatism Research Center Berlin, a Leibniz Institute - DRFZ, Schwiete laboratory for microbiota and inflammation, Berlin, Germany.
Beatrice EngelmannDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Germany.
Stephanie Serena SchaepeDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Germany.
Ulrike Rolle-KampczykDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Germany.
Nico JehmlichDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Germany.
Hyun-Dong ChangGerman Rheumatism Research Center Berlin, a Leibniz Institute - DRFZ, Schwiete laboratory for microbiota and inflammation, Berlin, Germany.
Ulla SlaninaFraunhofer Cluster of Excellence Immune-mediated Diseases - CIMD, Leipzig, Germany.
Maximillian HoffmanFraunhofer Cluster of Excellence Immune-mediated Diseases - CIMD, Leipzig, Germany.
Jörg LehmannFraunhofer Cluster of Excellence Immune-mediated Diseases - CIMD, Leipzig, Germany.
Ana Claudia ZenclussenHelmholtz-Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany.
Gunda HerberthHelmholtz-Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany.
Martin von BergenDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Germany.
Sven-Bastiaan HaangeDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Germany.ORCID 0000-0003-2952-1152
Helmholtz Centre for Environmental Research · DEFraunhofer Research Institution for Materials Recycling and Resource Strategies IWKS · DEGerman Rheumatism Research Centre · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of inflammatory bowel disease (IBD) is rising globally; however, its etiology is still not fully understood. Patient genetics, immune system, and intestinal microbiota are considered critical factors contributing to IBD. Preclinical animal models are crucial to better understand the importance of individual contributing factors. Among these, the dextran sodium sulfate (DSS) colitis model is the most widely used. DSS treatment induces gut inflammation and dysbiosis. However, its exact mode of action remains unclear. To determine whether DSS treatment induces pathogenic changes in the microbiota, we investigated the microbiota-modulating effects of DSS on murine microbiota

Indexed as

ColitisGastrointestinal MicrobiomeInflammatory Bowel DiseasesMicrobiotaAnimalsColonDextran SulfateDisease Models, AnimalHumansInflammationMiceMice, Inbred C57BLDextran SulfatebioreactorDSS colitisIBDin vitro modelmetabolomicsmetaproteomicsmicrobiota

Identifiers

PMID38165179
PMCPMC10763643
OpenAlexW4390499662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.