Evidence map›Paper›PMID 38165146›Full record

ArticleJournal of the American Geriatrics Society2024

Association between surgery and rate of incident dementia in older adults: A population-based retrospective cohort study.

Krista M Reich, Sudeep S Gill, Roderic Eckenhoff, Miles Berger, Peter C Austin, Paula A Rochon, Paul Nguyen, Zahra Goodarzi, Dallas P Seitz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Geriatrics Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Krista M ReichDivision of Geriatric Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Sudeep S GillDivision of Geriatric Medicine, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Roderic EckenhoffDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Miles BergerDepartment of Anesthesiology, Duke Center for the Study of Aging and Human Development, and the Duke/UNC Alzheimer's Disease Research Center, Duke University Medical Centre, Durham, North Carolina, USA.
Peter C AustinICES, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Paula A RochonICES, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.ORCID 0000-0002-5973-4151
Paul NguyenICES Queen's, Queen's University, Kingston, Ontario, Canada.
Zahra GoodarziDivision of Geriatric Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Dallas P SeitzICES Queen's, Queen's University, Kingston, Ontario, Canada.

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI CATHLEEN S COLON-EMERIC, Susan Nicole Hastings · 2006 to 2026
$24.6M
Research Education Component CoreP30AG072958 · NIA · DUKE UNIVERSITY · PI Heather E. Whitson · 2021 to 2026
$24.1M
Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI StudiesK76AG057022 · NIA · DUKE UNIVERSITY · PI BERGER, MILES · 2017 to 2022
$1.4M
NIA NIH HHS K76 AG057022NIA NIH HHS P30 AG028716NIA NIH HHS P30 AG072958
6 · The paper itself

Abstract

backgroundThe risk of incident dementia after surgery in older adults is unclear. The study objective was to examine the rate of incident dementia among older adults after elective surgery compared with a matched nonsurgical control group.

methodsWe conducted a population-based, propensity-matched retrospective cohort study using data from linked administrative databases in Ontario, Canada. All community-dwelling individuals aged 66 years and older who underwent one of five major elective surgeries between April 1, 2007 and March 31, 2011 were included. Each surgical patient was matched 1:1 on surgical specialty of the surgeon at consultation, age, sex, fiscal year of entry, and propensity score with a patient who attended an outpatient visit with a surgeon of the same surgical specialty but did not undergo surgery. Patients were followed for up to 5 years after cohort entry for the occurrence of a new dementia diagnosis, defined from administrative data. Cause-specific hazard models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for the association between surgery and the hazard of incident dementia. Subgroup and sensitivity analyses were performed.

resultsA total of 27,878 individuals (13,939 matched pairs) were included in the analysis. A total of 640 (4.6%) individuals in the surgical group and 965 (6.9%) individuals in the control group developed dementia over the 5-year follow-up period. Individuals who underwent surgery had a reduced rate of incident dementia compared with their matched nonsurgical controls (HR 0.88; 95% CI 0.80-0.97; p = 0.01). This association was persistent in most subgroups and after sensitivity analyses.

conclusionsElective surgery did not increase the rate of incident dementia when compared with matched nonsurgical controls. This could be an important consideration for patients and surgeons when elective surgery is considered.

Indexed as

DementiaElective Surgical ProceduresPropensity ScoreAgedAged, 80 and overFemaleHumansIncidenceMaleOntarioPostoperative ComplicationsRetrospective StudiesRisk FactorsAlzheimer's diseaseanesthesiacohort studydementiaolder adultssurgery

Identifiers

PMID38165146
PMCPMC11090718

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.