Evidence map›Paper›PMID 38165034›Full record

ArticleThe Journal of clinical investigation2024

Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation.

Samuel Young, Christian Schiffer, Alice Wagner, Jannika Patz, Anton Potapenko, Leonie Herrmann, Verena Nordhoff, Tim Pock, Claudia Krallmann, Birgit Stallmeyer and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
21.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 4 institutions in 2 countries.

Samuel YoungCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Christian SchifferCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Alice WagnerCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Jannika PatzCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Anton PotapenkoCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Leonie HerrmannCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Verena NordhoffCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Tim PockCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Claudia KrallmannCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Birgit StallmeyerInstitute of Reproductive Genetics.
Albrecht RöpkeInstitute of Human Genetics.
Michelina KierzekCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Cristina BiagioniCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Tao WangCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Lars HaalckInstitute of Geoinformatics, Computer Vision and Machine Learning Systems, University of Münster, Münster, Germany.
Dirk DeusterDepartment of Phoniatrics and Pedaudiology, University Hospital Münster, University of Münster, Münster, Germany.
Jan N HansenInstitute of Innate Immunity, Department of Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany.
Dagmar WachtenInstitute of Innate Immunity, Department of Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany.
Benjamin RisseInstitute of Geoinformatics, Computer Vision and Machine Learning Systems, University of Münster, Münster, Germany.
Hermann M BehreUKM Fertility Centre, University Hospital Münster, Münster, Germany.
Stefan SchlattCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Sabine KlieschCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Frank TüttelmannInstitute of Reproductive Genetics.
Christoph BrenkerCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
Timo StrünkerCentre of Reproductive Medicine and Andrology, University Hospital Münster, University of Münster, Münster, Germany.
University of Münster · DEReproductive Genetics Institute · USUniversity of Bonn · DEUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The infertility of many couples rests on an enigmatic dysfunction of the man's sperm. To gain insight into the underlying pathomechanisms, we assessed the function of the sperm-specific multisubunit CatSper-channel complex in the sperm of almost 2,300 men undergoing a fertility workup, using a simple motility-based test. We identified a group of men with normal semen parameters but defective CatSper function. These men or couples failed to conceive naturally and upon medically assisted reproduction via intrauterine insemination and in vitro fertilization. Intracytoplasmic sperm injection (ICSI) was, ultimately, required to conceive a child. We revealed that the defective CatSper function was caused by variations in CATSPER genes. Moreover, we unveiled that CatSper-deficient human sperm were unable to undergo hyperactive motility and, therefore, failed to penetrate the egg coat. Thus, our study provides the experimental evidence that sperm hyperactivation is required for human fertilization, explaining the infertility of CatSper-deficient men and the need of ICSI for medically assisted reproduction. Finally, our study also revealed that defective CatSper function and ensuing failure to hyperactivate represents the most common cause of unexplained male infertility known thus far and that this sperm channelopathy can readily be diagnosed, enabling future evidence-based treatment of affected couples.

Indexed as

Infertility, MaleSemenCalcium ChannelsChildFertilizationFertilization in VitroHumansMaleSpermatozoaSperm MotilityCalcium ChannelsCalcium channelsCell BiologyFertilityReproductive Biology

Identifiers

PMID38165034
PMCPMC10760960
OpenAlexW4390508175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.