Evidence map›Paper›PMID 38165011›Full record

ArticleEuropean journal of neurology2024

Impact of 2021 European Academy of Neurology/Peripheral Nerve Society diagnostic criteria on diagnosis and therapy of chronic inflammatory demyelinating polyradiculoneuropathy variants.

Alberto De Lorenzo, Giuseppe Liberatore, Pietro Emiliano Doneddu, Fiore Manganelli, Dario Cocito, Chiara Briani, Raffaella Fazio, Anna Mazzeo, Angelo Schenone, Vincenzo Di Stefano and 32 more

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In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 1 country.

Alberto De LorenzoNeuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.ORCID 0000-0002-9479-9444
Giuseppe LiberatoreNeuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.ORCID 0000-0003-2666-1678
Pietro Emiliano DonedduNeuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
Fiore ManganelliDepartment of Neuroscience, Reproductive Sciences, and Odontostomatology, University of Naples "Federico II", Naples, Italy.ORCID 0000-0002-1442-9604
Dario CocitoDepartment of Neuroscience, University of Turin, Turin, Italy.ORCID 0000-0002-6964-618X
Chiara BrianiNeurology Unit, Department of Neuroscience, University of Padua, Padua, Italy.ORCID 0000-0001-8035-0200
Raffaella FazioDivision of Neuroscience, Department of Neurology, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy.
Anna MazzeoDepartment of Clinical and Experimental Medicine, Unit of Neurology, University of Messina, Messina, Italy.
Angelo SchenoneNeurology Clinic, IRCCS Ospedale Policlinico San Martino Genova, Genoa, Italy.
Vincenzo Di StefanoDepartment of Biomedicine, Neuroscience, and Advanced Diagnostics, University of Palermo, Palermo, Italy.
Giuseppe CosentinoDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Girolama Alessandra MarfiaDysimmune Neuropathies Unit, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
Luana BenedettiNeurology Clinic, IRCCS Ospedale Policlinico San Martino Genova, Genoa, Italy.ORCID 0000-0002-9540-9727
Marinella CarpoDepartment of Neurology, ASST Bergamo Ovest-Ospedale Treviglio, Treviglio, Italy.
Massimiliano FilostoCenter for Neuromuscular Diseases and Neuropathies, Unit of Neurology, ASST "Spedali Civili", University of Brescia, Brescia, Italy.ORCID 0000-0002-2852-7512
Giovanni AntoniniUnit of Neuromuscular Diseases, Department of Neurology Mental Health and Sensory Organs, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Sant'Andrea Hospital, Rome, Italy.
Angelo Maurizio ClericiNeurology Unit, Circolo and Macchi Foundation Hospital, University of Insubria, Varese, Italy.
Marco LuigettiNeurology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0001-7539-505X
Sabrina MatàNeurology Unit, Dipartimento Neuromuscoloscheletrico e Degli Organi di Senso, University Hospital Careggi, Florence, Italy.
Tiziana RossoUOC di Neurologia, Ospedale San Bassano, Vicenza, Italy.
Marta LucchettaUOC Neurologia, Ospedale Santa Maria della Misericordia, Rovigo, Italy.
Gabriele SicilianoNeurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Giuseppe Lauria PinterUnit of Neuroalgology, IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy.ORCID 0000-0001-9773-020X
Guido CavalettiSchool of Medicine and Surgery and Experimental Neurology Unit, University of Milano-Bicocca, Monza, Italy.
Maurizio InghilleriNeurodegenerative Diseases Unit, Department of Human Neuroscience, Sapienza University, Policlinico Universitario Umberto I, Rome, Italy.
Teresa CantisaniServizio di Neurofisiopatologia, Azienda Ospedaliera di Perugia, Perugia, Italy.
Francesca NotturnoUOC Neurologia, Ospedale Santi Filippo e Nicola, Avezzano, Italy.
Dario RicciardiDivision of Neurology and Neurophysiopathology, Department of Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Francesco HabetswallnerClinical Neurophysiology Unit, Cardarelli Hospital, Naples, Italy.
Emanuele SpinaDepartment of Neuroscience, Reproductive Sciences, and Odontostomatology, University of Naples "Federico II", Naples, Italy.
Erdita PeciDepartment of Neuroscience, University of Turin, Turin, Italy.
Alessandro SalvalaggioNeurology Unit, Department of Neuroscience, University of Padua, Padua, Italy.
Yuri FalzoneDivision of Neuroscience, Department of Neurology, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy.
Camilla StranoDivision of Neuroscience, Department of Neurology, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy.
Luca GentileDepartment of Clinical and Experimental Medicine, Unit of Neurology, University of Messina, Messina, Italy.
Elisa VegezziIRCCS Mondino Foundation, Pavia, Italy.ORCID 0000-0001-8776-6831
Giorgia MataluniDysimmune Neuropathies Unit, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
Stefano Cotti PiccinelliCenter for Neuromuscular Diseases and Neuropathies, Unit of Neurology, ASST "Spedali Civili", University of Brescia, Brescia, Italy.
Luca LeonardiUnit of Neuromuscular Diseases, Department of Neurology Mental Health and Sensory Organs, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Sant'Andrea Hospital, Rome, Italy.ORCID 0000-0002-1267-864X
Angela RomanoNeurology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0002-2061-1509
Eduardo Nobile-OrazioNeuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
Italian CIDP Database Study Group
Vita-Salute San Raffaele University · ITAzienda Ospedaliera Sant'Andrea · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITFederico II University Hospital · ITIRCCS Humanitas Research Hospital · ITOspedale Policlinico San Martino · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Messina · ITUniversity of Milan · ITUniversity of Padua · ITUniversity of Rome Tor Vergata · ITUniversity of Turin · ITAzienda Ospedaliera di Perugia · ITAzienda Ospedaliera Treviglio · ITAzienda Ospedaliero-Universitaria Careggi · ITHumanitas University · ITOspedale Antonio Cardarelli · ITOspedale San Carlo · ITOspedale San Filippo Neri · ITOspedale Santa Maria della Misericordia di Rovigo · IT

Funding

CSL BehringGBS/CIDP Foundation InternationalHumanitas Clinical and Research Institute (Milan, Italy)Kedrion BiopharmaMinistero della Salute Ricerca Finalizzata (Progetto RF-2016-02361887)Regione Lombardia
6 · The paper itself

Abstract

background and purposeThere are different criteria for the diagnosis of different variants of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The 2021 European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) guidelines provide specific clinical criteria for each CIDP variant even if their therapeutical impact has not been investigated.

methodsWe applied the clinical criteria for CIDP variants of the 2021 EAN/PNS guidelines to 369 patients included in the Italian CIDP database who fulfilled the 2021 EAN/PNS electrodiagnostic criteria for CIDP.

resultsAccording to the 2021 EAN/PNS clinical criteria, 245 patients achieved a clinical diagnosis of typical CIDP or CIDP variant (66%). We identified 106 patients with typical CIDP (29%), 62 distal CIDP (17%), 28 multifocal or focal CIDP (7%), four sensory CIDP (1%), 27 sensory-predominant CIDP (7%), 10 motor CIDP (3%), and eight motor-predominant CIDP (2%). Patients with multifocal, distal, and sensory CIDP had milder impairment and symptoms. Patients with multifocal CIDP had less frequently reduced conduction velocity and prolonged F-wave latency and had lower levels of cerebrospinal fluid protein. Patients with distal CIDP more frequently had reduced distal compound muscle action potentials. Patients with motor CIDP did not improve after steroid therapy, whereas those with motor-predominant CIDP did. None of the patients with sensory CIDP responded to steroids, whereas most of those with sensory-predominant CIDP did.

conclusionsThe 2021 EAN/PNS criteria for CIDP allow a better characterization of CIDP variants, permitting their distinction from typical CIDP and more appropriate treatment for patients.

Indexed as

Polyradiculoneuropathy, Chronic Inflammatory DemyelinatingDatabases, FactualHumansNeural ConductionPeripheral Nerveschronic inflammatory demyelinating polyradiculoneuropathychronic inflammatory demyelinating polyradiculoneuropathy variantsdiagnostic criteriaEuropean Academy of Neurologyintravenous immunoglobulinLewis-Sumner syndromePeripheral Nerve Societysteroids

Identifiers

PMID38165011
PMCPMC11235819
OpenAlexW4390498647

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.