Observational studyBMJ open diabetes research & care2023
Comorbid status in patients with osteomyelitis is associated with long-term incidence of extremity amputation.
Observational study in BMJ open diabetes research & care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Clinical, etiological, and microbiological differences between foot and non-foot osteomyelitis.Archives of orthopaedic and trauma surgery · 2026Article
- Rationales for Antibiotic Treatment Versus Direct Surgical Resection in Various Strata of Diabetic Foot Osteomyelitis-Literature Review and Expert Opinions.Antibiotics (Basel, Switzerland) · 2026Article
- Clinical outcomes of dalbavancin versus standard therapy for non-severe skin and soft-tissue infections as well as bone and joint infections: a retrospective observational study.JAC-antimicrobial resistance · 2026Article
- Bone and Infections: An Osteoimmunological Interplay.International journal of molecular sciences · 2026Review
- Diagnostic value of neutrophil to lymphocyte ratio and serum biomarkers in chronic osteomyelitis.Scientific reports · 2025Article
- Incidence of chronic osteomyelitis between 2016 and 2022 in a large, multicenter database in the United States.Journal of bone and joint infection · 2025Article
- Femoral alloprosthesis in bone defect of 30 cm as extremity salvage.Trauma case reports · 2024Article
- Analysis of epidemiological and clinical aspects in cases of fungal osteomyelitis caused by non-Candida species.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
introductionOsteomyelitis is associated with significant morbidity, including amputation. There are limited data on long-term amputation rates following an osteomyelitis diagnosis. We sought to determine the incidence of amputation in patients with osteomyelitis over 2 years. RESEARCH DESIGN AND
methodsObservational cohort study of 1186 inpatients with osteomyelitis between 2004 and 2015 and stratified by osteomyelitis location status to evaluate the impact on amputation, mortality rates, readmission data, and inpatient days.
resultsPersons with diabetes had 3.65 times greater probability of lower extremity amputation (p<0.001), readmission (p<0.001), and longer inpatient stay (p<0.001) and had higher 2-year mortality (relative risk (RR) 1.23, p=0.0027), adjusting for risk factors. Male gender (RR 1.57, p<0.001), black race (RR 1.41, p<0.05), former smoking status (RR 1.38, p<0.01), myocardial infarction (RR 1.72, p<0.001), congestive heart failure (RR 1.56, p<0.001), peripheral vascular disease (RR 2.25, p<0.001) and renal disease (RR 1.756, p<0.001) were independently associated with amputation. Male gender (RR 1.39, p<0.01), black race (RR 1.27, p<0.05), diabetes (RR 2.77, p<0.001) and peripheral vascular disease (RR 1.59, p<0.001) had increased risk of lower, not upper, extremity amputation.
conclusionsPatients with osteomyelitis have higher rates of amputation and hospitalization. Clinicians must incorporate demographic and comorbid risk factors to protect against amputation.
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