ArticleMolecular pharmacology2024
Expression of Ceramide Synthases in Mice and Their Roles in Regulating Acyl-Chain Sphingolipids: A Framework for Baseline Levels and Future Implications in Aging and Disease.
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Article in Molecular pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- Targeted metabolomics identifies associations of plasma ceramides and their ratios with incident type 2 diabetes mellitus.Acta diabetologica · 2026Article
- Hypothalamic ceramide metabolism in obesity and dysregulation of glucose homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- Sphingolipid signaling in kidney diseases.American journal of physiology. Renal physiology · 2025Review
- Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia.ACS pharmacology & translational science · 2025Article
- Article
- Potential Vitamin E Signaling Mediators in Skeletal Muscle.Antioxidants (Basel, Switzerland) · 2024Review
- Ceramides-Emerging Biomarkers of Lipotoxicity in Obesity, Diabetes, Cardiovascular Diseases, and Inflammation.Diseases (Basel, Switzerland) · 2024Review
- Application of sphingolipid-based nanocarriers in drug delivery: an overview.Therapeutic delivery · 2024Review
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Whitney J RichardsonDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.).
Sophia B HumphreyDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.).
Sophia M SearsDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.).
Nicholas A HoffmanDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.).
Andrew J OrwickDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.).
Mark A DollDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.).
Chelsea L DollDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.).
Catherine XiaDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.).
Maria Hernandez-CorbachoDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.).
Justin M SniderDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.).
Lina M ObeidDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.).
Yusuf A HannunDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.).
Ashley J SniderDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.) ashleysnider@arizona.edu leah.siskind@louisville.edu.ORCID 0000-0002-1515-4171
Leah J SiskindDepartment of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, Kentucky (W.J.R., S.B.H., S.M.S., N.A.H., A.J.O., M.A.D., L.J.S.); Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York (M.H.-C., L.M.O., Y.A.H.); Northport Veteran Affairs Medical Center, Northport, New York (L.M.O., Y.A.H.); School of Nutritional Sciences, College of Agriculture, Life and Environmental Sciences, and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona (C.L.D., C.X., J.M.S., A.J.S.); and Brown Cancer Center, University of Louisville, Louisville, Kentucky (L.J.S.) ashleysnider@arizona.edu leah.siskind@louisville.edu.ORCID 0000-0001-5026-5187
University of Arizona · US
Funding
VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2MTranslational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7MSphingolipids in Cancer Therapy and AngiogenesisP01CA097132 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI Daniel Canals · 2003 to 2026
$30.8MNeutral Sphingomyelinases and Bioactive CeramidesR35GM118128 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI HANNUN, YUSUF AWNI · 2016 to 2025
$7.9MRESEARCH PILOT PROJECTS PROGRAMP30GM103339 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI OGRETMEN, BESIM · 2012 to 2016
$5.4MCeramide Activated Protein PhosphatasesR01CA218678 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI YUSUF AWNI HANNUN · 2018 to 2026
$3.4MThe role of neutral ceramidase in acute kidney injury and its progression to chronic kidney disease.R01DK124112 · NIDDK · UNIVERSITY OF LOUISVILLE · PI SISKIND, LEAH J · 2020 to 2023
$2.1MRole of Ceramide-induced Kidney Cell Death in Acute Kidney InjuryR01DK093462 · NIDDK · UNIVERSITY OF LOUISVILLE · PI SISKIND, LEAH J · 2012 to 2016
$1.6MSphingolipids, Dietary Fatty Acids, and Intestinal PathophysiologyR01DK130971 · NIDDK · UNIVERSITY OF ARIZONA · PI SNIDER, ASHLEY JONES · 2022 to 2025
$1.3MSummer Endocrine Research Training ProgramT35DK072923 · NIDDK · UNIVERSITY OF LOUISVILLE · PI KLINGE, CAROLYN M. · 2006 to 2025
$719kNCI NIH HHS P01 CA097132NCI NIH HHS P30 CA023074NCI NIH HHS P30 CA138313NCI NIH HHS R01 CA218678NIDDK NIH HHS R01 DK093462NIDDK NIH HHS R01 DK124112NIDDK NIH HHS R01 DK130971NIDDK NIH HHS T35 DK072923NIGMS NIH HHS P30 GM103339NIGMS NIH HHS R35 GM118128
Abstract
Sphingolipids are an important class of lipids present in all eukaryotic cells that regulate critical cellular processes. Disturbances in sphingolipid homeostasis have been linked to several diseases in humans. Ceramides are central in sphingolipid metabolism and are largely synthesized by six ceramide synthase (CerS) isoforms (CerS1-6), each with a preference for different fatty acyl chain lengths. Although the tissue distribution of CerS mRNA expression in humans and the roles of CerS isoforms in synthesizing ceramides with different acyl chain lengths are known, it is unknown how CerS expression dictates ceramides and downstream metabolites within tissues. In this study, we analyzed sphingolipid levels and CerS mRNA expression in 3-month-old C57BL/6J mouse brain, heart, kidney, liver, lung, and skeletal muscle. The results showed that CerS expression and sphingolipid species abundance varied by tissue and that CerS expression was a predictor of ceramide species within tissues. Interestingly, although CerS expression was not predictive of complex sphingolipid species within all tissues, composite scores for CerSs contributions to total sphingolipids measured in each tissue correlated to CerS expression. Lastly, we determined that the most abundant ceramide species in mouse tissues aligned with CerS mRNA expression in corresponding human tissues (based on chain length preference), suggesting that mice are relevant preclinical models for ceramide and sphingolipid research. SIGNIFICANCE STATEMENT: The current study demonstrates that ceramide synthase (CerS) expression in specific tissues correlates not only with ceramide species but contributes to the generation of complex sphingolipids as well. As many of the CerSs and/or specific ceramide species have been implicated in disease, these studies suggest the potential for CerSs as therapeutic targets and the use of sphingolipid species as diagnostics in specific tissues.
Indexed as
CeramidesOxidoreductasesSphingolipidsAgingAnimalsHumansInfantMiceMice, Inbred C57BLProtein IsoformsRNA, MessengerCeramidesdihydroceramide desaturaseOxidoreductasesProtein IsoformsRNA, MessengerSphingolipids
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