Evidence map›Paper›PMID 38164592›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

Peptide Receptor Radionuclide Therapy Is Effective for Clinical Control of Symptomatic Metastatic Insulinoma: A Long-Term Retrospective Analysis.

Liene Friebe, Martin T Freitag, Martin Braun, Guillaume Nicolas, Andreas Bauman, David Bushnell, Emanuel Christ, Damian Wild

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  5. Pancreatic neuroendocrine tumors: A case-based evidence review.World journal of gastrointestinal pathophysiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Liene FriebeClinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
Martin T FreitagClinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
Martin BraunClinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
Guillaume NicolasClinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
Andreas BaumanClinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
David BushnellDivision of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa; and.
Emanuel ChristENETS Center of Excellence for Neuroendocrine and Endocrine Tumors, University Hospital Basel, Basel, Switzerland.
Damian WildClinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland; damian.wild@usb.ch.
University Hospital of Basel · CHUniversity Medical Center Freiburg · DEUniversity of Iowa Hospitals and Clinics · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
NCI NIH HHS P30 CA086862
6 · The paper itself

Abstract

Metastatic insulinoma is a rare malignant neuroendocrine tumor characterized by inappropriate insulin secretion, resulting in life-threatening hypoglycemia, which is often difficult to treat. There is currently very limited information about the efficacy of peptide receptor radionuclide therapy (PRRT) for clinical control of hypoglycemia. The aim of this long-term retrospective study was to evaluate the therapeutic efficacy of PRRT for improving hypoglycemia, to evaluate the change of medication after PRRT, and to calculate progression-free survival (PFS) and overall survival (OS).

Indexed as

HypoglycemiaInsulinomaNeuroendocrine TumorsOrganometallic CompoundsPancreatic NeoplasmsHumansHypoglycemic AgentsOctreotideRadioisotopesReceptors, PeptideRetrospective StudiesTreatment OutcomeHypoglycemic AgentsOctreotideOrganometallic CompoundsRadioisotopesReceptors, Peptide[177Lu]Lu-DOTATOC[90Y]Y-DOTATOCmalignant insulinomaPRRT

Identifiers

PMID38164592
PMCPMC13671384
OpenAlexW4390048273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.