Evidence map›Paper›PMID 38164585›Full record

ArticleThe British journal of ophthalmology2024

Association of foveal avascular zone change and glaucoma progression.

Takashi Nishida, Sasan Moghimi, Evan Walker, Gopikasree Gunasegaran, Jo-Hsuan Wu, Alireza Kamalipour, Golnoush Mahmoudinezhad, Linda M Zangwill, Robert N Weinreb

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Takashi NishidaUniversity of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, USA.ORCID 0000-0002-8312-6623
Sasan MoghimiUniversity of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, USA.ORCID 0000-0002-9375-4711
Evan WalkerUniversity of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, USA.ORCID 0000-0001-8566-0371
Gopikasree GunasegaranUniversity of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, USA.
Jo-Hsuan WuUniversity of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, USA.ORCID 0000-0002-9435-746X
Alireza KamalipourUniversity of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, USA.
Golnoush MahmoudinezhadUniversity of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, USA.
Linda M ZangwillUniversity of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, USA.ORCID 0000-0002-1143-5224
Robert N WeinrebUniversity of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, USA rweinreb@ucsd.edu.ORCID 0000-0001-9553-3202
University of California San Diego · US

Funding

Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progressionR01EY026574 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2017 to 2020
$2.6M
Monitoring of Glaucoma Patients in Advanced DiseaseR01EY034148 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sasan Moghimi Araghi · 2022 to 2026
$2.5M
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY026574NEI NIH HHS R01 EY027510NEI NIH HHS R01 EY029058NEI NIH HHS R01 EY034148
6 · The paper itself

Abstract

BACKGROUND/

aimsTo investigate the association between longitudinal changes of foveal avascular zone (FAZ) area and the rate of structural and functional progression in glaucoma.

methodsA longitudinal cohort included 115 eyes (46 glaucoma suspect and 66 primary open-angle glaucoma) of 81 patients having ≥2 year follow-up, and ≥4 visits with optical coherence tomography angiography and visual field (VF). Eyes in the longitudinal cohort with a slope greater than that found in 95 percentile of separate healthy test-retest series for FAZ area were categorised into FAZ progressors; all other eyes were defined as FAZ non-progressors. A generalised linear mixed-effect model was used to investigate the association of FAZ progressors with demographic and clinical characteristics.

resultsFaster ganglion cell complex (GCC) thinning and faster VF mean deviation (MD) loss were found in eyes with FAZ progressors compared with FAZ non-progressors (mean difference: -0.7 (95% CI, -1.4 to -0.1) µm/y; p=0.026, -0.3 (-0.5 to -0.1) dB/y; p=0.017, respectively), while whole image vessel density was not associated with FAZ progressors (p=0.929). SD of intraocular pressure (IOP) and IOP range were also associated with FAZ progressors in separate multivariable models (OR: 1.54 (1.02 to 2.32) per 1 mm Hg higher, p=0.041; OR: 1.20 (1.01 to 1.41) per 1 mm Hg higher; p=0.035, respectively).

conclusionsSignificant FAZ increase was weakly associated with moderately faster rates of both GCC thinning and VF MD loss, but not macular vessel density change in glaucoma eyes. Additional studies are needed to elucidate the pathophysiological associations between macula GCC thinning and FAZ area increases in glaucoma.

Indexed as

Disease ProgressionFovea CentralisGlaucoma, Open-AngleIntraocular PressureRetinal Ganglion CellsRetinal VesselsTomography, Optical CoherenceVisual FieldsAgedFemaleFluorescein AngiographyFollow-Up StudiesHumansMaleMiddle AgedNerve FibersGlaucoma

Identifiers

PMID38164585
PMCPMC11192860
OpenAlexW4390100784

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.