Evidence map›Paper›PMID 38164584›Full record

ArticleMolecular pharmacology2024

Signaling Specificity and Kinetics of the Human Metabotropic Glutamate Receptors.

Tyler W McCullock, Loren P Cardani, Paul J Kammermeier

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. G protein signaling capabilities at the bradykinin 2 receptor.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tyler W McCullockDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York.ORCID 0000-0003-1628-1102
Loren P CardaniDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York.
Paul J KammermeierDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York Paul_kammermeier@urmc.rochester.edu.ORCID 0000-0002-8191-2284
University of Rochester Medical Center · US

Funding

A novel system for controlling dimeric receptor composition to discover unique heterodimer pharmacologyR01MH125849 · NIMH · UNIVERSITY OF ROCHESTER · PI KAMMERMEIER, PAUL J. · 2023 to 2025
$1.2M
New Tools for Studying Receptor DimersR21NS126779 · NINDS · UNIVERSITY OF ROCHESTER · PI KAMMERMEIER, PAUL J., LUECK, JOHN D. · 2022 to 2023
$407k
Tools for studying the regulation of Homer protein splicingR03NS124987 · NINDS · UNIVERSITY OF ROCHESTER · PI KAMMERMEIER, PAUL J. · 2021 to 2021
$154k
NIMH NIH HHS R01 MH125849NINDS NIH HHS R03 NS124987NINDS NIH HHS R21 NS126779
6 · The paper itself

Abstract

Metabotropic glutamate receptors (mGluRs) are obligate dimer G protein coupled receptors that can all function as homodimers. Here, each mGluR homodimer was examined for its G protein coupling profile using a bioluminescence resonance energy transfer-based assay that detects the interaction between a split YFP-tagged G

Indexed as

GTP-Binding ProteinsSignal TransductionCarrier ProteinsHumansPertussis ToxinCarrier ProteinsGTP-Binding ProteinsPertussis Toxin

Identifiers

PMID38164584
PMCPMC10794986
OpenAlexW4389475330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.