Evidence map›Paper›PMID 38164552›Full record

ArticleeNeuro2024

Gordon Holmes Syndrome Model Mice Exhibit Alterations in Microglia, Age, and Sex-Specific Disruptions in Cognitive and Proprioceptive Function.

Arlene J George, Wei Wei, Dhanya N Pyaram, Morgan Gomez, Nitheyaa Shree, Jayashree Kadirvelu, Hannah Lail, Desiree Wanders, Anne Z Murphy, Angela M Mabb

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Arlene J GeorgeNeuroscience Institute, Georgia State University, Atlanta 30302, Georgia.
Wei WeiNeuroscience Institute, Georgia State University, Atlanta 30302, Georgia.
Dhanya N PyaramNeuroscience Institute, Georgia State University, Atlanta 30302, Georgia.
Morgan GomezNeuroscience Institute, Georgia State University, Atlanta 30302, Georgia.
Nitheyaa ShreeNeuroscience Institute, Georgia State University, Atlanta 30302, Georgia.ORCID https://orcid.org/0000-0002-9681-6308
Jayashree KadirveluNeuroscience Institute, Georgia State University, Atlanta 30302, Georgia.
Hannah LailDepartment of Nutrition, Georgia State University, Atlanta 30303, Georgia.
Desiree WandersDepartment of Nutrition, Georgia State University, Atlanta 30303, Georgia.
Anne Z MurphyNeuroscience Institute, Georgia State University, Atlanta 30302, Georgia.ORCID https://orcid.org/0000-0003-2889-503X
Angela M MabbNeuroscience Institute, Georgia State University, Atlanta 30302, Georgia amabb@gsu.edu.ORCID https://orcid.org/0000-0002-3000-8690
Georgia State University · US

Funding

Impact of advanced age on opiate analgesiaR01DA041529 · NIDA · GEORGIA STATE UNIVERSITY · PI MURPHY, ANNE Z · 2017 to 2021
$1.8M
Insights into Gordon Holmes syndrome by substrate profiling of Triad3A and Chip using Orthogonal Ubiquitin TransferR21NS116760 · NINDS · GEORGIA STATE UNIVERSITY · PI MABB, ANGELA M, YIN, JUN · 2021 to 2021
$429k
NIDA NIH HHS R01 DA041529NINDS NIH HHS R21 NS116760
6 · The paper itself

Abstract

Gordon Holmes syndrome (GHS) is a neurological disorder associated with neuroendocrine, cognitive, and motor impairments with corresponding neurodegeneration. Mutations in the E3 ubiquitin ligase

Indexed as

Cerebellar AtaxiaHypogonadismMicrogliaAnimalsCognitionFemaleGonadotropin-Releasing HormoneMaleMiceMice, KnockoutUbiquitin-Protein LigasesGonadotropin-Releasing HormoneRNF216 protein, mouseUbiquitin-Protein LigasesataxiacognitiveGordon Holmes syndromemicrogliaRNF216ubiquitin

Identifiers

PMID38164552
PMCPMC10849025
OpenAlexW4390263405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.