Evidence map›Paper›PMID 38164539›Full record

ArticleeNeuro2024

Affection of Motor Network Regions by Tau Pathology Across the Alzheimer's Disease Spectrum.

Gérard N Bischof, Elena Jaeger, Kathrin Giehl, Merle C Hönig, Alzheimer’s Disease Neuroimaging Initiative, Peter H Weiss, Alexander Drzezga

Open access · goldAbstract read
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Neural basis of motor symptoms in Alzheimer's disease: role of regional tau burden and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Gérard N BischofDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50937 Cologne, Germany gerard.bischof@uk-koeln.de.ORCID https://orcid.org/0000-0002-4366-5171
Elena JaegerDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50937 Cologne, Germany.
Kathrin GiehlDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50937 Cologne, Germany.
Merle C HönigDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50937 Cologne, Germany.
Alzheimer’s Disease Neuroimaging Initiative
Peter H WeissCognitive Neuroscience, Institute for Neuroscience and Medicine III, Research Center Juelich, 52428 Juelich,Germany.
Alexander DrzezgaDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50937 Cologne, Germany.
Forschungszentrum Jülich · DEUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stereotypical isocortical tau protein pathology along the Braak stages has been described as an instigator of neurodegeneration in Alzheimer's disease (AD). Less is known about tau pathology in motor regions, although higher-order motor deficits such as praxis dysfunction are part of the clinical description. Here, we examined how tau pathology in cytoarchitectonically mapped regions of the primary and higher-order motor network in comparison to primary visual and sensory regions varies across the clinical spectrum of AD. We analyzed tau PET scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort in patients with mild cognitive impairment (MCI;

Indexed as

Alzheimer DiseaseCognitive DysfunctionAmyloid beta-PeptidesHumansNeuroimagingPositron-Emission Tomographytau ProteinsAmyloid beta-Peptidestau ProteinsAlzheimer's diseasemild cognitive impairmentmotor regionspositron emission tomographyregional tau burden

Identifiers

PMID38164539
PMCPMC10849022
OpenAlexW4389474308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.