Evidence map›Paper›PMID 38163962›Full record

ArticleParasitology2024

Altered larval activation response associated with multidrug resistance in the canine hookworm

Elise L McKean, Emilia Grill, Young-Jun Choi, Makedonka Mitreva, Damien M O'Halloran, John M Hawdon

Abstract read
In one paragraph

Article in Parasitology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Differential Emodepside Efficacy in Drug-Resistant and Drug-SusceptibleTropical medicine and infectious disease · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elise L McKeanDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, USA.
Emilia GrillDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, USA.
Young-Jun ChoiInfectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Makedonka MitrevaInfectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Damien M O'HalloranDepartment of Biological Sciences, The George Washington University, Washington, DC, USA.
John M HawdonDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, USA.ORCID 0000-0002-6164-1413

Funding

Population genomics and new tools for the endgame of onchocerciasis elimination in AfricaR01AI144161 · NIAID · WASHINGTON UNIVERSITY · PI GRANT, WARWICK, MITREVA, MAKEDONKA · 2020 to 2025
$3.3M
Development of a rodent model for anthelmintic testing against multidrug resistant hookwormsR21AI173403 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI HAWDON, JOHN M · 2023 to 2024
$444k
Identification and validation of mutations causing naturally occurring multi-drug resistance in hookwormR21AI137771 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI HAWDON, JOHN M, O'HALLORAN, DAMIEN M · 2018 to 2019
$439k
NIAID NIH HHS R01 AI144161NIAID NIH HHS R21 AI137771NIAID NIH HHS R21 AI173403NIH HHS 5 R21 AI137771NIH HHS R01AI144161
6 · The paper itself

Abstract

Parasitic gastrointestinal nematodes pose significant health risks to humans, livestock, and companion animals, and their control relies heavily on the use of anthelmintic drugs. Overuse of these drugs has led to the emergence of resistant nematode populations. Herein, a naturally occurring isolate (referred to as BCR) of the dog hookworm,

Indexed as

AncylostomaAnthelminticsAncylostomatoideaAnimalsDogsDrug ResistanceDrug Resistance, MultipleHumansLarvaAnthelminticsAncylostoma caninumbenzimidazoledog hookwormmacrocyclic lactonemultiple anthelmintic drug resistantpyrantel

Identifiers

PMID38163962
PMCPMC11007283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.