ReviewStress biology2024
Alternatives to antibiotics in pig production: looking through the lens of immunophysiology.
Review in Stress biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Evaluation of Dietary Supplementation with a Blend of Organic Acids and Cinnamaldehyde on Performance and Health Status in Weaned Piglets.Animals : an open access journal from MDPI · 2026Article
- Antibiotic exposure during weaning disrupts oral microbiota assembly in piglets.Journal of animal science and biotechnology · 2026Article
- Growth Performance and Antioxidant Responses to Dietary Flavonoids in Swine: A Systematic Review and Meta-Analysis with Exploratory Dose-Time Relationships.Antioxidants (Basel, Switzerland) · 2026Review
- Moderate DietaryAnimals : an open access journal from MDPI · 2026Article
- Metagenome-assembled genomes, and gene and protein catalogues from the global wild boar faecal microbiome.Scientific data · 2026Article
- Metagenomic insights into the global wild boar faecal microbiome reveal novel taxa and carbohydrate degraders distinguishing wild and domesticated Sus.Microbiome · 2026Article
- Review
- Antimicrobial peptides: structure, functions and translational applications.Nature reviews. Microbiology · 2025Review
- Gut health management in livestock: roles of probiotics, prebiotics, and synbiotics in growth, immunity, and microbiota modulation.Veterinary research communications · 2025Review
- Intestinal microbiota dynamics in piglets: the interplay with swine enteric coronavirus infections and implications for disease control.Animal microbiome · 2025Review
- Effects of Tributyrin on Antioxidant Capacity, Immune Function, and Liver Macrophage Polarization in Weaned Piglets Under LPS Challenge.Animals : an open access journal from MDPI · 2025Article
- Maple Syrup and Bacillus velezensis based Supplement: in Vivo Study of the Impact on Growth Performance, Microbiota Composition, and Metabolic Activity in Weaned Piglets.Current microbiology · 2025Article
- Effects of Magnolia officinalis extract on the growth performance and immune function of weaned piglets.Porcine health management · 2025Article
- Supplementation with Potato Protein Concentrate andAnimals : an open access journal from MDPI · 2025Article
- Effects of Dietary Supplementation withAnimals : an open access journal from MDPI · 2025Article
- Control of Neonatal Diarrhea in Piglets with Reduced Antibiotic Use by Application of a Complementary Feed-A Randomized Controlled Farm Trial.Veterinary sciences · 2025Article
- Article
- Protective activity of galacto-oligosaccharides against intestinal damage and inflammation induced by enterotoxigenicFrontiers in veterinary science · 2025Article
- Probiotics in miRNA-Mediated Regulation of Intestinal Immune Homeostasis in Pigs: A Physiological Narrative.Microorganisms · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
In the livestock production system, the evolution of porcine gut microecology is consistent with the idea of "The Hygiene Hypothesis" in humans. I.e., improved hygiene conditions, reduced exposure to environmental microorganisms in early life, and frequent use of antimicrobial drugs drive immune dysregulation. Meanwhile, the overuse of antibiotics as feed additives for infectious disease prevention and animal growth induces antimicrobial resistance genes in pathogens and spreads related environmental pollutants. It justifies our attempt to review alternatives to antibiotics that can support optimal growth and improve the immunophysiological state of pigs. In the current review, we first described porcine mucosal immunity, followed by discussions of gut microbiota dynamics during the critical weaning period and the impacts brought by antibiotics usage. Evidence of in-feed additives with immuno-modulatory properties highlighting probiotics, prebiotics, and phytobiotics and their cellular and molecular networking are summarized and reviewed. It may provide insights into the immune regulatory mechanisms of antibiotic alternatives and open new avenues for health management in pig production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.