Evidence map›Paper›PMID 38163634›Full record

ReviewThe Plant cell2024

Salicylic acid in plant immunity and beyond.

Steven H Spoel, Xinnian Dong

Open access · hybridAbstract readReview
In one paragraph

Review in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
92.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 154 citations in OpenAlex.

  1. Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Steven H SpoelInstitute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, The King's Buildings, Edinburgh EH9 3BF, UK.ORCID 0000-0003-4340-7591
Xinnian DongDepartment of Biology, Howard Hughes Medical Institute, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-1120-0951
Howard Hughes Medical Institute · USUniversity of Edinburgh · GB

Funding

Salicylic Acid in Immunity and Health: A Small Phytohormone with Big Physiological ImpactsR35GM118036 · NIGMS · DUKE UNIVERSITY · PI Xinnian Dong · 2016 to 2026
$4.0M
Biotechnology and Biological Sciences Research Council BB/S016767/1European Research Council 101001137Howard Hughes Medical InstituteNIGMS NIH HHS R35 GM118036NIH HHS NIH 1R35GM118036
6 · The paper itself

Abstract

As the most widely used herbal medicine in human history and a major defence hormone in plants against a broad spectrum of pathogens and abiotic stresses, salicylic acid (SA) has attracted major research interest. With applications of modern technologies over the past 30 years, studies of the effects of SA on plant growth, development, and defence have revealed many new research frontiers and continue to deliver surprises. In this review, we provide an update on recent advances in our understanding of SA metabolism, perception, and signal transduction mechanisms in plant immunity. An overarching theme emerges that SA executes its many functions through intricate regulation at multiple steps: SA biosynthesis is regulated both locally and systemically, while its perception occurs through multiple cellular targets, including metabolic enzymes, redox regulators, transcription cofactors, and, most recently, an RNA-binding protein. Moreover, SA orchestrates a complex series of post-translational modifications of downstream signaling components and promotes the formation of biomolecular condensates that function as cellular signalling hubs. SA also impacts wider cellular functions through crosstalk with other plant hormones. Looking into the future, we propose new areas for exploration of SA functions, which will undoubtedly uncover more surprises for many years to come.

Indexed as

Plant ImmunitySalicylic AcidSignal TransductionGene Expression Regulation, PlantPlant Growth RegulatorsPlant ProteinsPlantsPlant Growth RegulatorsPlant ProteinsSalicylic Acid

Identifiers

PMID38163634
PMCPMC11062473
OpenAlexW4390485755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.