Evidence map›Paper›PMID 38162906›Full record

ArticleBrain communications2024

Non-motor symptoms in motor neuron disease: prevalence, assessment and impact.

Emily Beswick, Deborah Forbes, Micheala Johnson, Judith Newton, Rachel Dakin, Stella Glasmcher, Sharon Abrahams, Alan Carson, Siddharthan Chandran, Suvankar Pal

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06900959 (Transcranial Static Field Stimulation), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06900959 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Transcranial Static Field Stimulation (tSMS) and Transcranial Direct Current Stimulation (tDCS) for the Treatment of Neurological Symptoms

TypeinterventionalSponsorNeuromed IRCCSRan2025 to 2026Enrolled40ConditionsNeurological Diseases or ConditionsArmstranscranial static field stimulation (tSMS) and transcranial (tDCS)
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Observational
  4. Article
  5. Banking on My Voice: Life with Motor Neurone Disease.Healthcare (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. The spectrum of behavioral disorders in amyotrophic lateral sclerosis: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Emily BeswickCentre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0001-9843-0778
Deborah ForbesCentre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0003-2584-0236
Micheala JohnsonCentre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh, UK.
Judith NewtonCentre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh, UK.
Rachel DakinCentre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0002-3697-8516
Stella GlasmcherAnne Rowling Regenerative Neurology Clinic, the University of Edinburgh, Edinburgh, UK.
Sharon AbrahamsEuan MacDonald Centre for MND Research, the University of Edinburgh, Edinburgh, UK.
Alan CarsonCentre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh, UK.
Siddharthan ChandranCentre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh, UK.
Suvankar PalCentre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0003-4276-639X
Mott MacDonald (United Kingdom) · GBMRC Centre for Regenerative Medicine · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

People with motor neuron disease often experience non-motor symptoms that may occur secondary to, or distinct from, motor degeneration and that may significantly reduce quality of life, despite being under-recognized and evaluated in clinical practice. Non-motor symptoms explored in this population-based study include pain, fatigue, gastrointestinal issues, poor sleep, low mood, anxiety, problematic saliva, apathy, emotional lability, cognitive complaints and sexual dysfunction. People registered on the Clinical Audit Research and Evaluation of motor neuron disease platform, the Scottish Motor Neuron Disease Register, were invited to complete a questionnaire on non-motor symptoms and a self-reported Amyotrophic Lateral Sclerosis Functional Rating Scale. The questionnaire comprised a pre-defined list of 11 potential non-motor symptoms, with the opportunity to list additional symptoms. A total of 120 individuals participated in this cross-sectional study, a 39% response rate of those sent questionnaires (

Indexed as

impactmotor neuron diseasenon-motor symptomsprevalencesurvey

Identifiers

PMID38162906
PMCPMC10754319
OpenAlexW4389426640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.