Evidence map›Paper›PMID 38162827›Full record

ArticleFrontiers in physiology2023

The efficacy of intranasal leptin for opioid-induced respiratory depression depends on sex and obesity state.

Michele L Singer, Mi-Kyung Shin, Lenise J Kim, Carla Freire, O Aung, Huy Pho, Joshua A East, Frank P Sgambati, Alban Latremoliere, Luu V Pham and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Leptin alleviates obesity hypoventilationbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Michele L SingerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Mi-Kyung ShinDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Lenise J KimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Carla FreireDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
O AungDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Huy PhoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Joshua A EastThe Johns Hopkins Center for Interdisciplinary Sleep Research and Education (CISRE), Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Frank P SgambatiThe Johns Hopkins Center for Interdisciplinary Sleep Research and Education (CISRE), Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Alban LatremoliereDepartments of Neurosurgery and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States, United States.
Luu V PhamDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Vsevolod Y PolotskyDepartment of Anesthesiology and Critical Care Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, WA, United States.
Johns Hopkins University · USGeorge Washington University · US

Funding

Treatment of Sleep Apnea by Targeting Leptin SignalingR01HL128970 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MENDELOWITZ, DAVID, POLOTSKY, VSEVOLOD Y · 2015 to 2023
$5.4M
Multi-Institutional Training in Genetic/Genomic Approaches to Sleep DisordersT32HL110952 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHERVIN, RONALD D, MIGNOT, EMMANUEL J · 2013 to 2022
$5.0M
Sleep fragmentation by brief awakenings as a surrogate to measure neuropathic spontaneous painR01NS112266 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LATREMOLIERE, ALBAN A · 2020 to 2024
$1.9M
Impact of Nocturnal Hypoxemia on Glucose during Sleep in High Altitude Sleep Disordered BreathingK23HL155730 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Luu Van Pham · 2022 to 2026
$981k
Intranasal Leptin as A Novel Treatment of Opioid-Induced Respiratory DepressionR61HL156240 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POLOTSKY, VSEVOLOD Y · 2020 to 2020
$737k
Leptin Receptor Agonist as a Novel Prevention of Opioid Induced Respiratory DepressionR41DA056239 · NIDA · ARREVUS, INC. · PI KRAUS, CARL NEIL, POLOTSKY, VSEVOLOD Y · 2022 to 2022
$319k
NHLBI NIH HHS K23 HL155730NHLBI NIH HHS R01 HL128970NHLBI NIH HHS R61 HL156240NHLBI NIH HHS T32 HL110952NIDA NIH HHS R41 DA056239NINDS NIH HHS R01 NS112266
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

apnealeptinobesityopioidsrespiration

Identifiers

PMID38162827
PMCPMC10756673
OpenAlexW4389683668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.