Evidence map›Paper›PMID 38162790›Full record

ArticleACS omega2023

Synthesis and Evaluation of Biological Activities for a Novel 1,2,3,4-Tetrahydroisoquinoline Conjugate with Dipeptide Derivatives: Insights from Molecular Docking and Molecular Dynamics Simulations.

Sunil R Tivari, Siddhant V Kokate, José L Belmonte-Vázquez, Tushar Janardan Pawar, Harun Patel, Iqrar Ahmad, Manoj S Gayke, Rajesh S Bhosale, Vicky D Jain, Ghazala Muteeb and 2 more

Abstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Novel Peptide-Triazole Conjugates: Strategic Synthesis, Antimicrobial Properties, and Molecular Docking Study.Journal of peptide science : an official publication of the European Peptide Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sunil R TivariDepartment of Chemistry, Marwadi University, Rajkot, Gujarat 360003, India.
Siddhant V KokateDepartment of Chemistry, S.S.C. College, Junnar, Pune, Maharashtra 410502, India.
José L Belmonte-VázquezFacultad de Química, Universidad Nacional Autónoma de México, Circuito Escolar s/n, Ciudad Universitaria, Ciudad de México 04510, Mexico.
Tushar Janardan PawarRed de Estudios Moleculares Avanzados, Clúster Científico y Tecnológico BioMimic del Instituto de Ecología, A.C. Carretera Antigua a Coatepec 351, Xalapa, Veracruz91073, Mexico.
Harun PatelDepartment of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule, Maharashtra 425405, India.ORCID https://orcid.org/0000-0003-0920-1266
Iqrar AhmadDepartment of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule, Maharashtra 425405, India.
Manoj S GaykeDepartment of Chemistry, School of Science, Indrashil University, Mehsana, Gujarat 382715, India.
Rajesh S BhosaleDepartment of Chemistry, School of Science, Indrashil University, Mehsana, Gujarat 382715, India.
Vicky D JainDepartment of Chemistry, Marwadi University, Rajkot, Gujarat 360003, India.ORCID https://orcid.org/0000-0001-5682-8913
Ghazala MuteebDepartment of Nursing, College of Applied Medical Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.ORCID https://orcid.org/0000-0002-3328-3559
Enrique Delgado-AlvaradoMicro and Nanotechnology Research Center, Universidad Veracruzana, Blvd. Av. Ruiz Cortines No. 455 Fracc, Costa Verde, Boca del Río 94294, Mexico.ORCID https://orcid.org/0000-0002-6354-5222
Yashwantsinh JadejaDepartment of Chemistry, Marwadi University, Rajkot, Gujarat 360003, India.ORCID https://orcid.org/0000-0002-6072-0654

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptide synthesis has opened new frontiers in the quest for bioactive molecules with limitless biological applications. This study presents the synthesis of a series of novel isoquinoline dipeptides using advanced spectroscopic techniques for characterization. These compounds were designed with the goal of discovering unexplored biological activities that could contribute to the development of novel pharmaceuticals. We evaluated the biological activities of novel compounds including their antimicrobial, antibacterial, and antifungal properties. The results show promising activity against

Identifiers

PMID38162790
PMCPMC10753551

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.