Evidence map›Paper›PMID 38162514›Full record

ArticleBioactive materials2024

An insect sclerotization-inspired antifouling armor on biomedical devices combats thrombosis and embedding.

Nan Lyu, Daihua Deng, Yuting Xiang, Zeyu Du, Xiaohui Mou, Qing Ma, Nan Huang, Jing Lu, Xin Li, Zhilu Yang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nan LyuDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, Department of Cardiology, The Tenth Affiliated Hospital, Southern Medical University, Dongguan, Guangdong, 523059, China.
Daihua DengDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, Department of Cardiology, The Tenth Affiliated Hospital, Southern Medical University, Dongguan, Guangdong, 523059, China.
Yuting XiangDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, Department of Cardiology, The Tenth Affiliated Hospital, Southern Medical University, Dongguan, Guangdong, 523059, China.
Zeyu DuDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, Department of Cardiology, The Tenth Affiliated Hospital, Southern Medical University, Dongguan, Guangdong, 523059, China.
Xiaohui MouDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, Department of Cardiology, The Tenth Affiliated Hospital, Southern Medical University, Dongguan, Guangdong, 523059, China.
Qing MaDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, Department of Cardiology, The Tenth Affiliated Hospital, Southern Medical University, Dongguan, Guangdong, 523059, China.
Nan HuangDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, Department of Cardiology, The Tenth Affiliated Hospital, Southern Medical University, Dongguan, Guangdong, 523059, China.
Jing LuDepartment of Anesthesiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Xin LiDepartment of Cardiology, Third People's Hospital of Chengdu Affiliated to Southwest Jiaotong University, Chengdu, Sichuan, 610072, China.
Zhilu YangDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, Department of Cardiology, The Tenth Affiliated Hospital, Southern Medical University, Dongguan, Guangdong, 523059, China.
Wentai ZhangDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, Department of Cardiology, The Tenth Affiliated Hospital, Southern Medical University, Dongguan, Guangdong, 523059, China.
Southern Medical University · CNChengdu Third People's Hospital · CNUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thrombus formation and tissue embedding significantly impair the clinical efficacy and retrievability of temporary interventional medical devices. Herein, we report an insect sclerotization-inspired antifouling armor for tailoring temporary interventional devices with durable resistance to protein adsorption and the following protein-mediated complications. By mimicking the phenol-polyamine chemistry assisted by phenol oxidases during sclerotization, we develop a facile one-step method to crosslink bovine serum albumin (BSA) with oxidized hydrocaffeic acid (HCA), resulting in a stable and universal BSA@HCA armor. Furthermore, the surface of the BSA@HCA armor, enriched with carboxyl groups, supports the secondary grafting of polyethylene glycol (PEG), further enhancing both its antifouling performance and durability. The synergy of robustly immobilized BSA and covalently grafted PEG provide potent resistance to the adhesion of proteins, platelets, and vascular cells

Indexed as

AntifoulingInsect sclerotizationPhenol-polyamine chemistryTemporary interventional devicesUniversal armor

Identifiers

PMID38162514
PMCPMC10755681
OpenAlexW4389504724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.