Evidence map›Paper›PMID 38162447›Full record

ReviewFrontiers in neurology2023

Botulinum neurotoxin type A in the interdisciplinary treatment of sialorrhea in adults and children-update and practice recommendations.

Wolfgang H Jost, Tobias Bäumer, Andrea Bevot, Ulrich Birkmann, Carsten Buhmann, Maria Grosheva, Orlando Guntinas-Lichius, Rainer Laskawi, Sebastian Paus, Christina Pflug and 6 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 1 country.

Wolfgang H JostParkinson-Klinik Ortenau, Wolfach, Germany.
Tobias BäumerInstitute of Systemic Motor Science, CBBM, University of Lübeck, Lübeck, Germany.
Andrea BevotDepartment of Neuropediatrics and Developmental Medicine, University Children's Hospital Tübingen, Tübingen, Germany.
Ulrich BirkmannDepartment of Neurology, Schluckambulanz, GFO Clinics Troisdorf, Troisdorf, Germany.
Carsten BuhmannDepartment of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Maria GroshevaDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.
Orlando Guntinas-LichiusDepartment of Otorhinolaryngology, Jena University Hospital, Jena, Germany.
Rainer LaskawiDepartment of Otorhinolaryngology, University Hospital Göttingen, Göttingen, Germany.
Sebastian PausDepartment of Neurology, GFO Clinics Troisdorf, Troisdorf, Germany.
Christina PflugDepartment of Voice, Speech and Hearing Disorders, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
A Sebastian SchroederClinic for Child Neurology and Social Pediatrics, Child Center Maulbronn, Maulbronn, Germany.
Björn SpittauAnatomy and Cell Biology, Medical School OWL, Bielefeld University, Bielefeld, Germany.
Armin SteffenDepartment for Otorhinolaryngology, University of Lübeck, Lübeck, Germany.
Bernd WilkenDepartment of Pediatric Neurology, Klinikum Kassel, Kassel, Germany.
Martin WinterhollerDepartment of Neurology, Sana Hospital Rummelsberg, Nuremberg/Schwarzenbruck, Germany.
Steffen BerweckSpecialist Center for Pediatric Neurology, Neurorehabilitation and Epileptology, Schön Clinic, Vogtareuth, Germany.
Universität Hamburg · DEUniversity of Lübeck · DEAtos Medical · DEBielefeld University · DEJena University Hospital · DEKlinikum Kassel · DEParkinson-Klinik Ortenau · DESchön Klinik Vogtareuth · DESLK-Kliniken Heilbronn · DEUniversity Children's Hospital Tübingen · DEUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sialorrhea is defined as a chronic excessive flow of saliva from the mouth, often with adverse consequences for health and quality of life of patients. In addition to currently used non-drug treatment and systemic drugs, intraglandular Botulinum Neurotoxin A (BoNT/A) injections have been examined in case studies, controlled trials and clinical practice. Two pivotal Phase III trials recently led to market approval in the USA and EU for IncobotulinumtoxinA [Xeomin®, IncoBoNT/A,

Indexed as

BoNT/Abotulinum neurotoxin type Abotulinum toxinhypersalivationIncobotulinumtoxinApractice recommendationsquality of lifesialorrhea

Identifiers

PMID38162447
PMCPMC10757066
OpenAlexW4389686184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.