Evidence map›Paper›PMID 38162403›Full record

ArticleEuropean heart journal open2024

Mapping microarchitectural degeneration in the dilated ascending aorta with

Mofei Wang, Justin A Ching-Johnson, Hao Yin, Caroline O'Neil, Alex X Li, Michael W A Chu, Robert Bartha, J Geoffrey Pickering

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mofei WangRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St. N. London, Canada, N6A 5B7.
Justin A Ching-JohnsonRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St. N. London, Canada, N6A 5B7.
Hao YinRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St. N. London, Canada, N6A 5B7.
Caroline O'NeilRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St. N. London, Canada, N6A 5B7.
Alex X LiRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St. N. London, Canada, N6A 5B7.
Michael W A ChuDepartment of Surgery, Western University, 1151 Richmond St. N. London, Canada, N6A 3K7.
Robert BarthaRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St. N. London, Canada, N6A 5B7.
J Geoffrey PickeringRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St. N. London, Canada, N6A 5B7.ORCID https://orcid.org/0000-0001-6474-3274
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Thoracic aortic aneurysms (TAAs) carry a risk of catastrophic dissection. Current strategies to evaluate this risk entail measuring aortic diameter but do not image medial degeneration, the cause of TAAs. We sought to determine if the advanced magnetic resonance imaging (MRI) acquisition strategy, diffusion tensor imaging (DTI), could delineate medial degeneration in the ascending thoracic aorta. Methods and results: Porcine ascending aortas were subjected to enzyme microinjection, which yielded local aortic medial degeneration. These lesions were detected by DTI, using a 9.4 T MRI scanner, based on tensor disorientation, disrupted diffusion tracts, and altered DTI metrics. High-resolution spatial analysis revealed that fractional anisotropy positively correlated, and mean and radial diffusivity inversely correlated, with smooth muscle cell (SMC) and elastin content ( Conclusion:

Indexed as

Ascending aortic aneurysmDiffusion tensor imagingElastinGlycosaminoglycansSmooth muscle cells

Identifiers

PMID38162403
PMCPMC10755346
OpenAlexW4389330280

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.