ArticleCerebral circulation - cognition and behavior2023
Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults.
Article in Cerebral circulation - cognition and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Obesity as a catalyst for neurodegeneration.Nature metabolism · 2026Review
- Obesity-induced cognitive impairment: Underlying mechanisms and therapeutic prospects.Metabolism open · 2026Review
- Multivariate White Matter Microstructure Alterations in Older Adults with Coronary Artery Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- White Matter Microstructure Alterations in Older Adults With Dyslipidemia Associated With Cognitive and Locomotor Dysfunction Evaluated Using Neurite Orientation Dispersion and Density Imaging.Brain and behavior · 2025Article
- Should We Consider Neurodegeneration by Itself or in a Triangulation with Neuroinflammation and Demyelination? The Example of Multiple Sclerosis and Beyond.International journal of molecular sciences · 2024Review
- Global and Regional Sex-Related Differences, Asymmetry, and Peak Age of Brain Myelination in Healthy Adults.Journal of clinical medicine · 2024Article
- The cognitive neuroscience and neurocognitive rehabilitation of dance.BMC neuroscience · 2024Review
- Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review.Journal of neurochemistry · 2024Review
- Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging.Neurobiology of aging · 2024Article
- Editorial.Cerebral circulation - cognition and behavior · 2024Article
- Correlates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health.Cerebral circulation - cognition and behavior · 2024Article
- Current Perspectives: Obesity and Neurodegeneration - Links and Risks.Degenerative neurological and neuromuscular disease · 2023Review
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Authors and funding
14 authors.
Funding
Abstract
Metabolic syndrome (MetS) is a cluster of conditions that affects ∼25% of the global population, including excess adiposity, hyperglycemia, dyslipidemia, and elevated blood pressure. MetS is one of major risk factors not only for chronic diseases, but also for dementia and cognitive dysfunction, although the underlying mechanisms remain poorly understood. White matter is of particular interest in the context of MetS due to the metabolic vulnerability of myelin maintenance, and the accumulating evidence for the importance of the white matter in the pathophysiology of dementia. Therefore, we investigated the associations of MetS risk score and adiposity (combined body mass index and waist circumference) with myelin water fraction measured with myelin water imaging. In 90 cognitively and neurologically healthy adults (20-79 years), we found that both high MetS risk score and adiposity were correlated with lower myelin water fraction in late-myelinating prefrontal and associative fibers, controlling for age, sex, race, ethnicity, education and income. Our findings call for randomized clinical trials to establish causality between MetS, adiposity, and myelin content, and to explore the potential of weight loss and visceral adiposity reduction as means to support maintenance of myelin integrity throughout adulthood, which could open new avenues for prevention or treatment of cognitive decline and dementia.
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Registered trials
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