Evidence map›Paper›PMID 38162229›Full record

ReviewBiomicrofluidics2023

Microphysiological systems as reliable drug discovery and evaluation tools: Evolution from innovation to maturity.

Hye-Ran Moon, Nishanth Surianarayanan, Tarun Singh, Bumsoo Han

Abstract readReview
In one paragraph

Review in Biomicrofluidics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Integration of microphysiological systems with computational and digital twin modeling for pharmaceutical development: a systematic review.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hye-Ran MoonSchool of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0000-0001-7456-6398
Nishanth SurianarayananSchool of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.ORCID https://orcid.org/0009-0002-9717-0155
Tarun SinghSchool of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Reprogramming PDAC Stroma by Targeting Coagulation in the Tumor MicroenvironmentU01CA274304 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Melissa L. Fishel, Matthew J. Flick · 2022 to 2026
$4.6M
Targeting the Plasminogen Activation System to Limit Pancreatic Cancer Progression and Associated ThrombosisU01HL143403 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISHEL, MELISSA L., FLICK, MATTHEW J. · 2018 to 2022
$4.2M
Investigation of novel signaling protein in 3D and in vivo PDAC models using second generation Ref-1 inhibitorsR01CA254110 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI FISHEL, MELISSA L., HAN, BUMSOO · 2021 to 2025
$2.1M
Dynamic Circadian Regulation of the Blood-Brain Interface in a Human Brain-mimicking Microfluid ChipR61HL159948 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GILLETTE, MARTHA U, HAN, BUMSOO · 2021 to 2022
$1.7M
NCI NIH HHS P30 CA023168NCI NIH HHS R01 CA254110NCI NIH HHS U01 CA274304NHLBI NIH HHS R61 HL159948NHLBI NIH HHS U01 HL143403
6 · The paper itself

Abstract

Microphysiological systems (MPSs), also known as organ-on-chip or disease-on-chip, have recently emerged to reconstitute the

Identifiers

PMID38162229
PMCPMC10756708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.