Evidence map›Paper›PMID 38162083›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2023

[Inhibition of Histone Deacetylase 6 Ameliorates Podocyte Injury in Diabetic Kidney Disease in Mice].

Qing Hou, Shuyan Kan, Mingchao Zhang, Feng Xu, Zhihong Liu, Song Jiang

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Histone deacetylases and their inhibitors in kidney diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qing Hou（ 210016） National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing 210016, China.
Shuyan Kan（ 210016） National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing 210016, China.
Mingchao Zhang（ 210016） National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing 210016, China.
Feng Xu（ 210016） National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing 210016, China.
Zhihong Liu（ 210016） National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing 210016, China.
Song Jiang（ 210016） National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing 210016, China.
Jinling Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the role of histone deacetylase 6 (HDAC6) in podocyte injury in diabetic kidney disease (DKD) in mice. Methods: 1) The 8-week-old male CD-1 mice were selected to construct the model of DKD with streptozocin (STZ). After the model was established, the mice were intraperitoneally injected with HDAC6 inhibitor CAY10603 (5mg/kg/daily) or same volume vehicle as control. The mice were divided into four groups, control (CTL)+vehicle (Veh) ( Results: After 2 weeks of treatment, mice in the STZ+CAY10603 group exhibited reduction in uACR ( Conclusion: Inhibition of HDAC6 alleviates proteinuria and podocyte injury in the mouse model of DKD by suppressing the activation of NLRP3 inflammasome.

Indexed as

Diabetes MellitusDiabetic NephropathiesHistone Deacetylase 6PodocytesAnimalsCarbamatesHumansInflammasomesMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinOxazolesTransforming Growth Factor betaCarbamatesCAY10603Histone Deacetylase 6InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinOxazolesTransforming Growth Factor betaDiabetic kidney diseaseHistone deacetylase 6NLRP3 inflammasomePodocytes

Identifiers

PMID38162083
PMCPMC10752790
OpenAlexW4390508058

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.