Evidence map›Paper›PMID 38162021›Full record

ArticleiScience2023

Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection.

Jessica Vetters, Mary van Helden, Clint De Nolf, Sofie Rennen, Eva Cloots, Evelien Van De Velde, Farzaneh Fayazpour, Justine Van Moorleghem, Manon Vanheerswynghels, Karl Vergote and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 3 countries.

Jessica VettersLaboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Mary van HeldenDepartment of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Clint De NolfLaboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Sofie RennenLaboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Eva ClootsLaboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Evelien Van De VeldeLaboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Farzaneh FayazpourLaboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Justine Van MoorleghemDepartment of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Manon VanheerswynghelsDepartment of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Karl VergoteDepartment of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Louis BoonJJP Biologics, Warsaw, Poland.
Eric VivierAix Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Bart N LambrechtDepartment of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Sophie JanssensLaboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Ghent University Hospital · BECentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The unfolded protein response (UPR) aims to restore ER homeostasis under conditions of high protein folding load, a function primarily serving secretory cells. Additional, non-canonical UPR functions have recently been unraveled in immune cells. We addressed the function of the inositol-requiring enzyme 1 (IRE1) signaling branch of the UPR in NK cells in homeostasis and microbial challenge. Cell-intrinsic compound deficiency of IRE1 and its downstream transcription factor XBP1 in NKp46

Indexed as

ImmunologyMicrobiologyTranscriptomicsVirology

Identifiers

PMID38162021
PMCPMC10755724
OpenAlexW4388943023

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.