Evidence map›Paper›PMID 38161592›Full record

ArticleFrontiers in aging neuroscience2023

Sex moderates the association between age and myelin water fraction in the cingulum and fornix among older adults without dementia.

Einat K Brenner, Katherine J Bangen, Alexandra L Clark, Lisa Delano-Wood, Nicole D Evangelista, Lauren Edwards, Scott F Sorg, Amy J Jak, Mark W Bondi, Sean C L Deoni and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Einat K BrennerDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Katherine J BangenDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Alexandra L ClarkDepartment of Psychology, The University of Texas at Austin, Austin, TX, United States.
Lisa Delano-WoodDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Nicole D EvangelistaDepartment of Clinical and Health Psychology, Center for Cognitive Aging and Memory, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, Gainesville, FL, United States.
Lauren EdwardsJoint Doctoral Program in Clinical Psychology, San Diego State University/University of California San Diego, San Diego, CA, United States.
Scott F SorgHome Base, A Red Sox Foundation and Massachusetts General Hospital Program, Boston, MA, United States.
Amy J JakDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Mark W BondiDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Sean C L DeoniBill and Melinda Gates Foundation, Seattle, WA, United States.
Melissa LamarRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark W Bondi · 2019 to 2026
$34.9M
Intracranial arterial compliance, cerebral blood flow, and dementia risk in older adults with type 2 diabetesR01AG063782 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANGEN, KATHERINE · 2020 to 2024
$3.7M
Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial FindingsR01AG049810 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W, EDLAND, STEVEN DYAL · 2016 to 2020
$3.7M
The role of myelin & vascular risk on brain structure and function in agingK01AG040192 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAMAR, MELISSA · 2012 to 2015
$522k
Myelin markers and modifiable risks of vascular aging in African AmericansR21AG048176 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAMAR, MELISSA · 2015 to 2016
$455k
Identifying best methods for the detection of subtle cognitive declineR03AG070435 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THOMAS, KELSEY R · 2021 to 2022
$316k
CSRD VA I01 CX001842CSRD VA IK2 CX000938CSRD VA IK2 CX001865NIA NIH HHS K01 AG040192NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG049810NIA NIH HHS R01 AG063782NIA NIH HHS R03 AG070435NIA NIH HHS R21 AG048176
6 · The paper itself

Abstract

Background: Decreasing white matter integrity in limbic pathways including the fornix and cingulum have been reported in Alzheimer's disease (AD), although underlying mechanisms and potential sex differences remain understudied. We therefore sought to explore sex as a moderator of the effect of age on myelin water fraction (MWF), a measure of myelin content, in older adults without dementia ( Methods: Participants underwent neuropsychological evaluation and 3 T MRI at two research sites. Multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) quantified MWF in 3 Results: (1) There was a significant age by sex interaction on MWF of the fornix ( Conclusion: The current work adds to the literature by illuminating sex differences in age-related myelin decline using a measure sensitive to myelin and may help facilitate detection of AD risk for women.

Indexed as

agecingulumfornix (brain)memorymyelinmyelin water fraction (MWF)neuroimagingsex

Identifiers

PMID38161592
PMCPMC10757372

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.