Evidence map›Paper›PMID 38161581›Full record

ArticleThe Yale journal of biology and medicine2023

Early Chromatin Remodeling Events in Acutely Stimulated CD8

Bryan McDonald, Brent Y Chick, Diana C Hargreaves, Susan M Kaech

Open access · diamondAbstract read
In one paragraph

Article in The Yale journal of biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Bryan McDonaldNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Brent Y ChickMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Diana C HargreavesMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Susan M KaechNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Salk Institute for Biological Studies · USUniversity of California, San Diego · US

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8M
Pathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9M
Regulation of memory CD8 T cell developmentR37AI066232 · NIAID · YALE UNIVERSITY · PI KAECH, SUSAN M · 2013 to 2022
$5.4M
The role of BAF related complexes in regulatory T cell development and functionR01AI151123 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI HARGREAVES, DIANA CLARE, ZHENG, YE · 2020 to 2024
$4.0M
BD FACSAria Fusion for Flow Cytometry Core FacilityS10OD023689 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2018 to 2018
$530k
Chromatin remodeling in CD8+ T cells and harnessing stromal-immune interactions for effective antitumor immunityF99CA274688 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, BRYAN · 2022 to 2023
$47k
NCI NIH HHS F99 CA274688NCI NIH HHS P30 CA014195NIAID NIH HHS R01 AI151123NIAID NIH HHS R37 AI066232NIGMS NIH HHS T32 GM133351NIH HHS S10 OD023689
6 · The paper itself

Abstract

T cells undergo extensive chromatin remodeling over several days following stimulation through the T cell receptor. However, the kinetics and gene loci targeted by early remodeling events within the first 24 hours of T cell priming to orchestrate effector differentiation have not been well described. We identified that chromatin accessibility is rapidly and extensively remodeled within 1 hour of stimulation of naïve CD8

Indexed as

CD8-Positive T-LymphocytesChromatin Assembly and DisassemblyCell DifferentiationChromatinHumansSignal TransductionChromatinChromatin remodelingDifferentiationEpigeneticsT cells

Identifiers

PMID38161581
PMCPMC10751865
OpenAlexW4390484399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.